Leguire L E, Rogers G L, Bremer D L
Department of Ophthalmology, Children's Hospital, Columbus, Ohio, USA.
Doc Ophthalmol. 1995;89(3):277-86. doi: 10.1007/BF01203381.
Flash visual evoked responses were recorded and visual evoked response binocular summation was assessed in normal children between the ages of 1 and 58 months, in normal adults and in children with early-onset esotropia before and longitudinally for 1 year after surgical binocular alignment. Normal flash visual evoked response binocular summation started in the range of facilitation (> 2.0) at 1 month of age and decreased to adult levels by 3.7 months of age. The shape of the flash visual evoked response binocular summation function obtained from the patients with early-onset esotropia, appeared similar to that of normal subjects; however, the rapid decrease in flash visual evoked response binocular summation from facilitation to normal adult levels occurred after surgical binocular alignment. In normal adults, flash visual evoked response binocular summation was significantly reduced by a 40-diopter base-in prism, suggesting that binocular misalignment was not the reason for the facilitation in flash visual evoked response binocular summation in either childhood population. It is proposed that this facilitation may reflect a process that leads to binocularity and that develops rapidly with binocular alignment.
记录了1至58个月的正常儿童、正常成年人以及早发性内斜视儿童在手术双眼矫正前后及纵向随访1年期间的闪光视觉诱发电位，并评估了视觉诱发电位双眼总和。正常闪光视觉诱发电位双眼总和在1个月大时开始处于易化范围（>2.0），到3.7个月大时降至成人水平。早发性内斜视患者获得的闪光视觉诱发电位双眼总和功能的形状与正常受试者相似；然而，闪光视觉诱发电位双眼总和从易化迅速降至正常成人水平是在手术双眼矫正之后发生的。在正常成年人中，40棱镜底向内可显著降低闪光视觉诱发电位双眼总和，这表明双眼不对准不是这两个儿童群体中闪光视觉诱发电位双眼总和易化的原因。有人提出，这种易化可能反映了一个导致双眼视觉的过程，并且随着双眼矫正而迅速发展。
