Frolkis V V
Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kiev.
Exp Gerontol. 1995 May-Aug;30(3-4):401-14. doi: 10.1016/0531-5565(94)00068-e.
It has been shown that a number of hormones (insulin, testosterone, thyroxine, and adrenaline) can stimulate synthesis of plasma membrane regulators-- "invertors" in a cell. The synthesis of "invertors," which is under genomic control, decreases with age. As a result, insulin, testosterone, and thyroxine do not provoke Na,K-ATPase activation and plasma membrane hyperpolarization of hepatocytes and myocardiocytes in old rates. Also, due to desensitization of the heart to adrenaline, a smaller decrease occurs in adenylate cyclase activity in old animals. The Na,K-ATPase of plasma membranes of old animals maintain their ability to respond to the "invertors." The decrease in the synthesis of "invertors" represent an important mechanism of change in the cell's reaction to hormones.
已经表明，许多激素（胰岛素、睾酮、甲状腺素和肾上腺素）可以刺激质膜调节剂——细胞中的“转化器”的合成。在基因组控制下的“转化器”的合成会随着年龄的增长而减少。因此，胰岛素、睾酮和甲状腺素不会引起老年大鼠肝细胞和心肌细胞质膜超极化和钠钾ATP酶激活。此外，由于心脏对肾上腺素脱敏，老年动物的腺苷酸环化酶活性降低幅度较小。老年动物质膜的钠钾ATP酶保持了对“转化器”作出反应的能力。“转化器”合成的减少代表了细胞对激素反应变化的一个重要机制。
