Suppr超能文献

On the mechanism of thyroid hormone-induced respiratory burst activity in rat polymorphonuclear leukocytes.

作者信息

Fernández V, Videla L A

机构信息

Department of Biochemistry, Faculty of Medicine, University of Chile, Santiago.

出版信息

Free Radic Biol Med. 1995 Sep;19(3):359-63. doi: 10.1016/0891-5849(95)00016-q.

Abstract

Administration of single doses of 0.1 mg L-triiodothyronine (T3)/kg for 3 consecutive days to fed rats produced a drastic increase in the respiratory burst activity of isolated polymorphonuclear leukocytes (PMN), stimulated with serum-opsonized zymosan. This effect was evidenced by the 3.8-fold increment in the integrated chemiluminescence, and seems to be primarily related to the enhanced activity of NADPH oxidase elicited by T3 treatment, with the observed higher myeloperoxidase activity playing a contributory role. In these conditions, hyperthyroidism determines a net enhancement in the oxidant capacity of PMN, as the increased rate of O2.- generation found occurs in the absence of changes in the activity of superoxide dismutase.

摘要

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验