人类促性腺激素释放激素受体（GnRH-R）基因在标记物D4S392和D4S409之间定位于4q的亚区域图谱。
Subregional mapping of the human gonadotropin-releasing hormone receptor (GnRH-R) gene to 4q between the markers D4S392 and D4S409.
作者信息
Kottler M L, Lorenzo F, Bergametti F, Commerçon P, Souchier C, Counis R
机构信息
Endocrinologie Cellulaire et Moléculaire de la Reproduction, URA CNRS 1449, Paris, France.
出版信息
Hum Genet. 1995 Oct;96(4):477-80. doi: 10.1007/BF00191810.
We have isolated nine yeast artificial chromosomes (YACs) containing the gene that encodes the human gonadotropin-releasing hormone receptor (GnRH-R) gene by screening the YAC library of the Centre d'Etude du Polymorphisme Humain (Hôpital Saint-Louis, Paris, France) by the use of the polymerase chain reaction. We defined the location of the GnRH-R gene relative to 4q microsatellite markers D4S392 and D4S409. The genetic positions of these markers on chromosome 4 are 76 and 77 cM, respectively. This location was further established by chromosomal in situ hybridization.
我们通过聚合酶链反应筛选法国巴黎圣路易医院人类多态性研究中心的酵母人工染色体（YAC）文库，分离出了九个包含编码人促性腺激素释放激素受体（GnRH-R）基因的YAC。我们确定了GnRH-R基因相对于4号染色体微卫星标记D4S392和D4S409的位置。这些标记在4号染色体上的遗传位置分别为76和77厘摩。通过染色体原位杂交进一步确定了该位置。
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