半合成卡那霉素B衍生物阿贝卡星对耐甲氧西林金黄色葡萄球菌的活性。
Activity of the semi-synthetic kanamycin B derivative, arbekacin against methicillin-resistant Staphylococcus aureus.
作者信息
Hamilton-Miller J M, Shah S
机构信息
Department of Medical Microbiology, Royal Free Hospital School of Medicine, London, UK.
出版信息
J Antimicrob Chemother. 1995 Jun;35(6):865-8. doi: 10.1093/jac/35.6.865.
PMID:7559197
Abstract
Arbekacin (1-N-((S)-4-amino-2-hydroxybutyryl)-3',4'-dideoxykanamycin B) was active against 54 strains of methicillin-resistant Staphylococcus aureus from 16 different countries, all of which were resistant to > or = 32 mg/L amikacin. MICs of arbekacin ranged from 1 to 16 mg/L, the MIC50 was 3.2 mg/L and the mode geometric mean MICs were 4 and 4.5 mg/L respectively.
摘要
阿贝卡星（1-N-((S)-4-氨基-2-羟基丁酰基)-3',4'-二脱氧卡那霉素B）对来自16个不同国家的54株耐甲氧西林金黄色葡萄球菌有活性，所有这些菌株对阿米卡星的耐药浓度均≥32mg/L。阿贝卡星的最低抑菌浓度（MIC）范围为1至16mg/L，MIC50为3.2mg/L，几何平均MIC的众数分别为4mg/L和4.5mg/L。
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