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Apparent involvement of a multidrug transporter in the fluoroquinolone resistance of Streptococcus pneumoniae.多药转运蛋白明显参与肺炎链球菌对氟喹诺酮类药物的耐药性。
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Active efflux of antimicrobial agents in wild-type strains of enterococci.肠球菌野生型菌株中抗菌药物的主动外排
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Antimicrobial resistance in anaerobes.厌氧菌中的抗菌药物耐药性。
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In vitro susceptibility of anaerobes to quinolones in the United States.美国厌氧菌对喹诺酮类药物的体外敏感性
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Penetration of lipophilic agents with multiple protonation sites into bacterial cells: tetracyclines and fluoroquinolones as examples.具有多个质子化位点的亲脂性药物进入细菌细胞的机制：以四环素和氟喹诺酮类药物为例
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Multidrug resistance pumps in bacteria: variations on a theme.细菌中的多药耐药泵：同一主题的变体
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Mutants of the Bacillus subtilis multidrug transporter Bmr with altered sensitivity to the antihypertensive alkaloid reserpine.枯草芽孢杆菌多药转运蛋白Bmr的突变体，对降压生物碱利血平的敏感性发生改变。
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脆弱拟杆菌对诺氟沙星的主动外排

Active efflux of norfloxacin by Bacteroides fragilis.

作者信息

Miyamae S, Nikaido H, Tanaka Y, Yoshimura F

机构信息

Department of Microbiology, School of Dentistry, Aichi-Gakuin University, Nagoya 464-8650, Japan.

出版信息

Antimicrob Agents Chemother. 1998 Aug;42(8):2119-21. doi: 10.1128/AAC.42.8.2119.

DOI:10.1128/AAC.42.8.2119
PMID:9687419
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC105880/
Abstract

Norfloxacin was actively pumped out by Bacteroides fragilis, which is intrinsically resistant to most fluoroquinolones. Reserpine moderately inhibited the efflux. A one-step spontaneous mutant had increased resistance to norfloxacin, ethidium bromide, and puromycin, a result suggesting that the efflux is catalyzed by a multidrug pump with specificity similar to that of NorA/Bmr.

摘要

脆弱拟杆菌可主动泵出诺氟沙星，该菌对大多数氟喹诺酮类药物具有内在抗性。利血平可适度抑制这种外排作用。一个单步自发突变体对诺氟沙星、溴化乙锭和嘌呤霉素的抗性增强，这一结果表明该外排作用是由一种与NorA/Bmr特异性相似的多药泵催化的。