脆弱拟杆菌对诺氟沙星的主动外排
Active efflux of norfloxacin by Bacteroides fragilis.
作者信息
Miyamae S, Nikaido H, Tanaka Y, Yoshimura F
机构信息
Department of Microbiology, School of Dentistry, Aichi-Gakuin University, Nagoya 464-8650, Japan.
出版信息
Antimicrob Agents Chemother. 1998 Aug;42(8):2119-21. doi: 10.1128/AAC.42.8.2119.
Abstract
Norfloxacin was actively pumped out by Bacteroides fragilis, which is intrinsically resistant to most fluoroquinolones. Reserpine moderately inhibited the efflux. A one-step spontaneous mutant had increased resistance to norfloxacin, ethidium bromide, and puromycin, a result suggesting that the efflux is catalyzed by a multidrug pump with specificity similar to that of NorA/Bmr.
摘要
脆弱拟杆菌可主动泵出诺氟沙星，该菌对大多数氟喹诺酮类药物具有内在抗性。利血平可适度抑制这种外排作用。一个单步自发突变体对诺氟沙星、溴化乙锭和嘌呤霉素的抗性增强，这一结果表明该外排作用是由一种与NorA/Bmr特异性相似的多药泵催化的。
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