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Isolation and characterization of autolysis-defective mutants of Staphylococcus aureus created by Tn917-lacZ mutagenesis.通过Tn917-lacZ诱变产生的金黄色葡萄球菌自溶缺陷突变体的分离与鉴定。
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A Staphylococcus aureus autolysin that has an N-acetylmuramoyl-L-alanine amidase domain and an endo-beta-N-acetylglucosaminidase domain: cloning, sequence analysis, and characterization.一种具有N - 乙酰胞壁酰 - L - 丙氨酸酰胺酶结构域和内切β - N - 乙酰葡糖胺酶结构域的金黄色葡萄球菌自溶素：克隆、序列分析及特性鉴定
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7
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金黄色葡萄球菌8325/4主要自溶素的分子特征及功能分析

Molecular characterization and functional analysis of the major autolysin of Staphylococcus aureus 8325/4.

作者信息

Foster S J

机构信息

Department of Molecular Biology and Biotechnology, University of Sheffield, United Kingdom.

出版信息

J Bacteriol. 1995 Oct;177(19):5723-5. doi: 10.1128/jb.177.19.5723-5725.1995.

DOI:10.1128/jb.177.19.5723-5725.1995
PMID:7559367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC177389/
Abstract

The gene encoding the major autolysin of Staphylococcus aureus 8325/4 has been cloned, sequenced, and insertionally inactivated. The three-domain, 137,384-Da protein has a C-terminal glucosaminidase active site and is involved in cell separation, generalized cell lysis, and release of wall material at the cell surface. Expression occurs throughout growth and is stimulated by low temperatures and in the presence of 1 M NaCl.

摘要

编码金黄色葡萄球菌8325/4主要自溶素的基因已被克隆、测序并插入失活。这种由三个结构域组成、分子量为137,384道尔顿的蛋白质具有一个C端氨基葡萄糖苷酶活性位点，参与细胞分离、普遍的细胞裂解以及细胞壁物质在细胞表面的释放。该基因在整个生长过程中都有表达，并且在低温和1M氯化钠存在的情况下会受到刺激。