Marinello C P, Berglundh T, Ericsson I, Klinge B, Glantz P O, Lindhe J
Department of Periodontology, Faculty of Odontology, University of Göteborg, Sweden.
J Clin Periodontol. 1995 Jun;22(6):475-9. doi: 10.1111/j.1600-051x.1995.tb00180.x.
The present experiment in the Labrador dog was performed to study tissue alterations that occurred in a peri-implantitis lesion following ligature removal. The study was carried out in 5, 1-year old Labrador dogs. The mandibular right and left 1st molars and 4th and 3rd premolars were extracted to establish recipient sites for implants. After 3 months of healing, 4 titanium fixtures, 2 in each jaw quadrant, were installed and abutment connection carried out in a 2nd stage procedure after another 3 months. After a 6-month period of healing, cotton floss ligatures were placed in a submarginal position around the neck of the fixture abutments. The ligatures were forced into a position "apical" of the margin of the peri-implant mucosa and secured. When the tissue destruction after 4-6 weeks was found to amount to about 25% of the original bone height at each individual implant, the ligatures were removed. 2 dogs were sacrificed 1 month and 3 dogs 3 months after ligature removal. The animals were perfused with a fixative and block biopsies were obtained from the implant sites. The biopsies were prepared for histometric and morphometric analyses.(ABSTRACT TRUNCATED AT 250 WORDS)
在拉布拉多犬身上进行了本实验，以研究结扎去除后种植体周围炎病变中发生的组织改变。该研究在5只1岁的拉布拉多犬身上进行。拔除下颌左右第1磨牙以及第4和第3前磨牙，以建立种植体植入位点。愈合3个月后，植入4枚钛制种植体，每个颌象限各植入2枚，再过3个月后进行二期手术连接基台。经过6个月的愈合期后，将棉线结扎于种植体基台颈部的龈下位置。将结扎线置于种植体周围黏膜边缘的“根尖”位置并固定。当发现4至6周后每个种植体处的组织破坏达到原始骨高度的约25%时，拆除结扎线。结扎线拆除后1个月处死2只犬，3个月处死3只犬。对动物进行灌注固定，从种植体部位获取块状活检组织。对活检组织进行组织计量学和形态计量学分析。（摘要截选至250字）
