Requena L, Aguilar A, Renedo G, Martín L, Piqué E, Fariña M C, Escalonilla P
Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
J Dermatol. 1995 Jul;22(7):492-5.
Tripe palms is a distinctive paraneoplastic cutaneous sign which is frequently associated with internal malignancy, specially carcinomas of the lung and stomach. We describe a patient with ovary carcinoma who showed a curious rugose thickening of the palms with accentuation of the normal dermatoglyphic ridges. The lesions were a specially prominent on the fingertips. The patient also showed classical acanthosis nigricans in the axillae and groin. The soles were spared. Histopathologic findings in palmar lesions consisted of an undulant epidermis, with hyperkeratosis, acanthosis, and papillomatosis. Excision of the ovary carcinoma was followed by complete regression of the cutaneous lesions. We review the literature about tripe palms and discuss the relationship between this striking cutaneous manifestation and internal malignancy.
掌跖角化瘤是一种独特的副肿瘤性皮肤体征，常与体内恶性肿瘤相关，特别是肺癌和胃癌。我们描述了一名卵巢癌患者，其手掌出现奇特的皱缩增厚，正常皮纹嵴更加明显。这些病变在指尖尤为突出。患者腋窝和腹股沟还出现了典型的黑棘皮病。足底未受累。手掌病变的组织病理学表现为表皮呈波浪状，伴有角化过度、棘层肥厚和乳头瘤病。卵巢癌切除后，皮肤病变完全消退。我们回顾了关于掌跖角化瘤的文献，并讨论了这种显著皮肤表现与体内恶性肿瘤之间的关系。
