初始α/β T细胞在次级淋巴器官中的寿命。
The life span of naive alpha/beta T cells in secondary lymphoid organs.
作者信息
von Boehmer H, Hafen K
机构信息
Basel Institute for Immunology, Switzerland.
出版信息
J Exp Med. 1993 Apr 1;177(4):891-6. doi: 10.1084/jem.177.4.891.
Abstract
We have determined the life span of naive CD4-8+ T cells in T cell receptor transgenic mice. We find that such cells do not divide in secondary lymphoid organs in both normal euthymic mice and T cell-deficient mice. By both continuous labeling and by chasing pulse-labeled cells, we find that the minimum life span of the naive T cells is in the order of 8 wk.
摘要
我们已经确定了T细胞受体转基因小鼠中初始CD4-8+T细胞的寿命。我们发现，在正常胸腺正常的小鼠和T细胞缺陷小鼠的次级淋巴器官中，此类细胞均不分裂。通过连续标记和追踪脉冲标记的细胞，我们发现初始T细胞的最短寿命约为8周。
相似文献
1
The life span of naive alpha/beta T cells in secondary lymphoid organs.初始α/β T细胞在次级淋巴器官中的寿命。
J Exp Med. 1993 Apr 1;177(4):891-6. doi: 10.1084/jem.177.4.891.
2
Selection of phenotypically distinct NK1.1+ T cells upon antigen expression in the thymus or in the liver.在胸腺或肝脏中抗原表达后，对表型不同的NK1.1 + T细胞进行选择。
Eur J Immunol. 1999 Jul;29(7):2330-43. doi: 10.1002/(SICI)1521-4141(199907)29:07<2330::AID-IMMU2330>3.0.CO;2-G.
3
Both intrathymic and peripheral selection modulate the differential expression of V beta 5 among CD4+ and CD8+ T cells.胸腺内选择和外周选择均调节CD4⁺和CD8⁺T细胞中Vβ5的差异表达。
J Exp Med. 1992 Dec 1;176(6):1733-8. doi: 10.1084/jem.176.6.1733.
4
Critical role for the common cytokine receptor gamma chain in intrathymic and peripheral T cell selection.共同细胞因子受体γ链在胸腺内和外周T细胞选择中的关键作用。
J Exp Med. 1996 Mar 1;183(3):1111-8. doi: 10.1084/jem.183.3.1111.
5
Naive CD4+ T lymphocytes circulate through lymphoid organs to interact with endogenous antigens and upregulate their function.幼稚 CD4+ T 淋巴细胞循环通过淋巴器官与内源性抗原相互作用，并上调其功能。
J Immunol. 2010 May 1;184(9):4646-53. doi: 10.4049/jimmunol.0903946. Epub 2010 Mar 19.
6
Defect of thymocyte emigration in a T cell deficiency strain (CTS) of the mouse.小鼠T细胞缺陷品系（CTS）中胸腺细胞迁出缺陷
J Immunol. 1996 Oct 15;157(8):3412-9.
7
Expression of tissue-specific autoantigens in the hematopoietic cells leads to activation-induced cell death of autoreactive T cells in the secondary lymphoid organs.造血细胞中组织特异性自身抗原的表达导致次级淋巴器官中自身反应性T细胞的活化诱导细胞死亡。
Eur J Immunol. 2004 Nov;34(11):3126-34. doi: 10.1002/eji.200425177.
8
In vitro negative selection of alpha beta T cell receptor transgenic thymocytes by conditionally immortalized thymic cortical epithelial cell lines and dendritic cells.通过条件永生化胸腺皮质上皮细胞系和树突状细胞对αβT细胞受体转基因胸腺细胞进行体外阴性选择。
Eur J Immunol. 1993 Oct;23(10):2614-21. doi: 10.1002/eji.1830231035.
9
Population dynamics of T lymphocytes. Renewal rate and expansion in the peripheral lymphoid organs.T淋巴细胞的群体动力学。外周淋巴器官中的更新率和扩增
J Immunol. 1983 Nov;131(5):2158-64.
10
Allelic exclusion at DNA rearrangement level is required to prevent coexpression of two distinct T cell receptor beta genes.在DNA重排水平上的等位基因排斥是防止两个不同的T细胞受体β基因共表达所必需的。
J Exp Med. 1991 Oct 1;174(4):815-9. doi: 10.1084/jem.174.4.815.
引用本文的文献
1
Immune response to SARS-CoV-2 in severe disease and long COVID-19.重症疾病和新冠长期症状中对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的免疫反应。
iScience. 2022 Aug 19;25(8):104723. doi: 10.1016/j.isci.2022.104723. Epub 2022 Jul 4.
2
Agent-based modeling of the interaction between CD8+ T cells and Beta cells in type 1 diabetes.基于主体的1型糖尿病中CD8 + T细胞与β细胞相互作用的建模
PLoS One. 2018 Jan 10;13(1):e0190349. doi: 10.1371/journal.pone.0190349. eCollection 2018.
3
Arp2/3 complex controls T cell homeostasis by maintaining surface TCR levels via regulating TCR endosome trafficking.Arp2/3 复合物通过调节 TCR 内体运输来维持表面 TCR 水平，从而控制 T 细胞动态平衡。
Sci Rep. 2017 Aug 21;7(1):8952. doi: 10.1038/s41598-017-08357-4.
4
Modelling T cell proliferation: Dynamics heterogeneity depending on cell differentiation, age, and genetic background.模拟T细胞增殖：取决于细胞分化、年龄和遗传背景的动力学异质性。
PLoS Comput Biol. 2017 Mar 13;13(3):e1005417. doi: 10.1371/journal.pcbi.1005417. eCollection 2017 Mar.
5
The MicroRNA miR-191 Supports T Cell Survival Following Common γ Chain Signaling.微小RNA miR-191在共同γ链信号传导后支持T细胞存活。
J Biol Chem. 2016 Nov 4;291(45):23532-23544. doi: 10.1074/jbc.M116.741264. Epub 2016 Sep 15.
6
Analysis of naïve lung CD4 T cells provides evidence of functional lung to lymph node migration.分析初始肺脏 CD4 T 细胞为肺至淋巴结的功能迁移提供了证据。
Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1821-6. doi: 10.1073/pnas.1221306110. Epub 2013 Jan 14.
7
Quantifying T lymphocyte turnover.量化 T 淋巴细胞更新。
J Theor Biol. 2013 Jun 21;327:45-87. doi: 10.1016/j.jtbi.2012.12.025. Epub 2013 Jan 9.
8
HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo.HTLV-1 bZIP 因子在体内诱导 T 细胞淋巴瘤和全身炎症。
PLoS Pathog. 2011 Feb 10;7(2):e1001274. doi: 10.1371/journal.ppat.1001274.
9
Self-class I MHC molecules support survival of naive CD8 T cells, but depress their functional sensitivity through regulation of CD8 expression levels.I类自身主要组织相容性复合体（MHC）分子支持初始CD8⁺ T细胞的存活，但通过调节CD8表达水平降低其功能敏感性。
J Exp Med. 2009 Sep 28;206(10):2253-69. doi: 10.1084/jem.20082553. Epub 2009 Sep 14.
10
Modelling the human immune system by combining bioinformatics and systems biology approaches.通过结合生物信息学和系统生物学方法对人类免疫系统进行建模。
J Biol Phys. 2006 Oct;32(3-4):335-53. doi: 10.1007/s10867-006-9019-7. Epub 2006 Oct 27.
本文引用的文献
1
Circulating T and B lymphocytes of the mouse. II. Lifespan.小鼠循环T淋巴细胞和B淋巴细胞。II. 寿命。
Cell Immunol. 1973 Apr;7(1):40-59. doi: 10.1016/0008-8749(73)90181-0.
2
Lymphocyte population kinetics in the mouse.小鼠淋巴细胞群体动力学
Immunol Rev. 1986 Jun;91:5-37. doi: 10.1111/j.1600-065x.1986.tb01482.x.
3
Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes.T细胞受体转基因小鼠中的耐受性涉及未成熟CD4+8+胸腺细胞的缺失。
Nature. 1988 Jun 23;333(6175):742-6. doi: 10.1038/333742a0.
4
5
6
Thymic major histocompatibility complex antigens and the alpha beta T-cell receptor determine the CD4/CD8 phenotype of T cells.胸腺主要组织相容性复合体抗原和αβ T细胞受体决定T细胞的CD4/CD8表型。
Nature. 1988 Sep 15;335(6187):229-33. doi: 10.1038/335229a0.
7
Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production.人类记忆性T淋巴细胞表达三种细胞黏附分子（淋巴细胞功能相关抗原3、CD2和淋巴细胞功能相关抗原1）以及其他三种分子（泛素羧基末端水解酶L1、CDw29和P-糖蛋白1）的水平增加，且产生γ干扰素的能力增强。
J Immunol. 1988 Mar 1;140(5):1401-7.
8
The cellular basis of T-cell memory.T细胞记忆的细胞基础。
Annu Rev Immunol. 1989;7:77-89. doi: 10.1146/annurev.iy.07.040189.000453.
9
A monoclonal antibody to murine CD45R distinguishes CD4 T cell populations that produce different cytokines.一种针对小鼠CD45R的单克隆抗体可区分产生不同细胞因子的CD4 T细胞群体。
Eur J Immunol. 1989 Apr;19(4):617-23. doi: 10.1002/eji.1830190407.
10
Maintenance of B-cell memory by long-lived cells generated from proliferating precursors.由增殖前体产生的长寿细胞维持B细胞记忆。
Nature. 1990 Aug 23;346(6286):749-51. doi: 10.1038/346749a0.
Zotero 插件