血脑屏障的穿透：细菌糖肽对药物递送和成像的增强作用
Penetration of the blood-brain barrier: enhancement of drug delivery and imaging by bacterial glycopeptides.
作者信息
Spellerberg B, Prasad S, Cabellos C, Burroughs M, Cahill P, Tuomanen E
机构信息
Laboratory of Molecular Infectious Diseases, Rockefeller University, New York 10021, USA.
出版信息
J Exp Med. 1995 Oct 1;182(4):1037-43. doi: 10.1084/jem.182.4.1037.
Abstract
The blood-brain barrier restricts the passage of many pharmacological agents into the brain parenchyma. Bacterial glycopeptides induce enhanced blood-brain barrier permeability when they are present in the subarachnoid space during meningitis. By presenting such glycopeptides intravenously, blood-brain barrier permeability in rabbits was enhanced in a reversible time- and dose-dependent manner to agents < or = 20 kD in size. Therapeutic application of this bioactivity was evident as enhanced penetration of the antibiotic penicillin and the magnetic resonance imaging contrast agent gadolinium-diethylene-triamine-pentaacetic acid into the brain parenchyma.
摘要
血脑屏障限制了许多药理剂进入脑实质。细菌性糖肽在脑膜炎期间存在于蛛网膜下腔时会诱导血脑屏障通透性增强。通过静脉注射此类糖肽，家兔的血脑屏障通透性以可逆的时间和剂量依赖方式增强，对大小≤20 kD的药剂均有此作用。这种生物活性的治疗应用表现为抗生素青霉素和磁共振成像造影剂钆 - 二乙烯三胺五乙酸进入脑实质的渗透率增强。
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