Smits H L, Tjong-A-Hung S P, ter Schegget J, Nooter K, Kok T
Department of Virology, University of Amsterdam, Academic Medical Centre, The Netherlands.
J Med Virol. 1995 Jul;46(3):213-5. doi: 10.1002/jmv.1890460308.
Strong evidence has implicated human papillomaviruses (HPV) in the pathogenesis of anogenital cancers and a number of other mucosal and cutaneous lesions. Data concerning the involvement of HPV in esophageal cancers are controversial. Different investigators have detected HPV types (mainly types 16 and 18) in biopsy specimens of esophageal cancers. A study was undertaken to determine whether responses to chemotherapy of advanced squamous cell carcinomas could be correlated with the HPV status. Polymerase chain reaction (PCR) amplification was used for the detection of HPV DNA in biopsies of esophageal squamous cell carcinomas treated with either surgical resection alone (n = 42) or chemotherapy followed by surgical resection (n = 21). Different general and consensus PCR primer sets, which allow the detection of most of the known as well as a number of not yet characterized HPV types, were used. HPV DNA was not detected in any of the 61 esophageal squamous cell carcinomas, suggesting that HPV infections are not likely to play a major role in the etiology of this neoplasm.
有力证据表明，人乳头瘤病毒（HPV）与肛门生殖器癌以及许多其他黏膜和皮肤病变的发病机制有关。关于HPV与食管癌关系的数据存在争议。不同的研究人员在食管癌活检标本中检测到了HPV类型（主要是16型和18型）。开展了一项研究，以确定晚期鳞状细胞癌对化疗的反应是否与HPV状态相关。聚合酶链反应（PCR）扩增用于检测单纯手术切除（n = 42）或化疗后手术切除（n = 21）的食管鳞状细胞癌活检组织中的HPV DNA。使用了不同的通用和共识PCR引物组，这些引物组能够检测大多数已知的以及一些尚未鉴定的HPV类型。在61例食管鳞状细胞癌中均未检测到HPV DNA，这表明HPV感染不太可能在该肿瘤的病因学中起主要作用。
