奥布赖恩光化性肉芽肿：对异维甲酸的反应

Ratnavel R C, Grant J W, Handfield-Jones S E, Norris P G

Department of Dermatology, Addenbrooke's Hospital, Cambridge, UK.

J R Soc Med. 1995 Sep;88(9):528P-529P.

We describe a 75-year-old man demonstrating the florid clinical features of actinic granuloma of O'Brien. This rare disfiguring condition is believed to result from a granulomatous reaction of the dermis to solar-induced elastosis and is poorly responsive to topical steroids. Twelve weeks' treatment with isotretinoin prevented the development of new granulomata and produced almost complete resolution of established lesions.

我们描述了一名75岁男性，其表现出奥布赖恩光化性肉芽肿的典型临床特征。这种罕见的毁容性疾病被认为是真皮对日光诱导的弹性组织变性的肉芽肿反应所致，对局部类固醇治疗反应不佳。异维A酸治疗12周可预防新肉芽肿的形成，并使已形成的皮损几乎完全消退。