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奥布赖恩光化性肉芽肿：对异维甲酸的反应

O'Brien's actinic granuloma: response to isotretinoin.

作者信息

Ratnavel R C, Grant J W, Handfield-Jones S E, Norris P G

机构信息

Department of Dermatology, Addenbrooke's Hospital, Cambridge, UK.

出版信息

J R Soc Med. 1995 Sep;88(9):528P-529P.

PMID:7562853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1295336/
Abstract

We describe a 75-year-old man demonstrating the florid clinical features of actinic granuloma of O'Brien. This rare disfiguring condition is believed to result from a granulomatous reaction of the dermis to solar-induced elastosis and is poorly responsive to topical steroids. Twelve weeks' treatment with isotretinoin prevented the development of new granulomata and produced almost complete resolution of established lesions.

摘要

我们描述了一名75岁男性，其表现出奥布赖恩光化性肉芽肿的典型临床特征。这种罕见的毁容性疾病被认为是真皮对日光诱导的弹性组织变性的肉芽肿反应所致，对局部类固醇治疗反应不佳。异维A酸治疗12周可预防新肉芽肿的形成，并使已形成的皮损几乎完全消退。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f461/1295336/c4069274b9e1/jrsocmed00066-0051-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f461/1295336/28a6cd6cd0b4/jrsocmed00066-0050-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f461/1295336/337b83b9ea0f/jrsocmed00066-0051-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f461/1295336/c4069274b9e1/jrsocmed00066-0051-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f461/1295336/28a6cd6cd0b4/jrsocmed00066-0050-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f461/1295336/337b83b9ea0f/jrsocmed00066-0051-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f461/1295336/c4069274b9e1/jrsocmed00066-0051-b.jpg

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Actinic granuloma presenting as tender, linear plaques on the lateral fingers in a patient with newly diagnosed esophageal cancer.一名新诊断为食管癌的患者，光化性肉芽肿表现为手指外侧出现压痛性线状斑块。
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Actinic Granuloma with Focal Segmental Glomerulosclerosis.光化性肉芽肿伴局灶节段性肾小球硬化
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O'Brien Actinic Granuloma: A Case Report and Brief Review of Literature.

本文引用的文献

1
Restoration of collagen formation in photodamaged human skin by tretinoin (retinoic acid).维甲酸（视黄酸）对光损伤人类皮肤中胶原蛋白形成的修复作用。
N Engl J Med. 1993 Aug 19;329(8):530-5. doi: 10.1056/NEJM199308193290803.
2
Granuloma multiforme.多形性肉芽肿
Trans St Johns Hosp Dermatol Soc. 1969;55(1):88-98.
3
Necrobiosis lipoidica presenting on the face and scalp. An account of 29 patients and a detailed consideration of recent histochemical findings.面部和头皮出现的类脂质渐进性坏死。29例病例报告及近期组织化学研究结果详述
奥布赖恩光化性肉芽肿：一例报告及文献简要综述
Indian J Dermatol. 2015 Jul-Aug;60(4):391-3. doi: 10.4103/0019-5154.160493.
4
Actinic granuloma arising from the pulsed dye laser-treated skin in a patient with capillary malformation.一名患有毛细血管畸形的患者经脉冲染料激光治疗的皮肤出现光化性肉芽肿。
Ann Dermatol. 2015 Apr;27(2):214-6. doi: 10.5021/ad.2015.27.2.214. Epub 2015 Mar 24.
Trans St Johns Hosp Dermatol Soc. 1971;57(1):202-20.
4
Miescher's granuloma of the face. A variant of the necrobiosis lipoidica-granuloma annulare spectrum.面部米舍尔肉芽肿。类脂质渐进性坏死 - 环状肉芽肿谱系的一种变体。
Arch Dermatol. 1973 Jan;107(1):62-4.
5
Actinic granuloma (O'Brien).光化性肉芽肿（奥布赖恩病）
J Cutan Pathol. 1988 Apr;15(2):66-74. doi: 10.1111/j.1600-0560.1988.tb00522.x.
6
Resolution of disseminated granuloma annulare with isotretinoin.异维A酸治疗播散性环状肉芽肿有效。
Int J Dermatol. 1992 May;31(5):371-2. doi: 10.1111/j.1365-4362.1992.tb03970.x.
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Actinic granuloma. An annular connective tissue disorder affecting sun- and heat-damaged (elastotic) skin.光化性肉芽肿。一种影响受阳光和热损伤（弹性组织变性）皮肤的环形结缔组织疾病。
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8
Is actinic granuloma a specific condition?光化性肉芽肿是一种特殊病症吗？
Am J Dermatopathol. 1979 Spring;1(1):43-50.