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临床研究中良性前列腺增生的特定健康状况测量：美国泌尿外科学会症状指数和良性前列腺增生影响指数的多大变化对患者而言是可察觉的？

Benign prostatic hyperplasia specific health status measures in clinical research: how much change in the American Urological Association symptom index and the benign prostatic hyperplasia impact index is perceptible to patients?

作者信息

Barry M J, Williford W O, Chang Y, Machi M, Jones K M, Walker-Corkery E, Lepor H

机构信息

Medical Practices Evaluation Center, Massachusetts General Hospital, Boston, USA.

出版信息

J Urol. 1995 Nov;154(5):1770-4. doi: 10.1016/s0022-5347(01)66780-6.

DOI:10.1016/s0022-5347(01)66780-6
PMID:7563343
Abstract

PURPOSE

We assessed the relationship between changes in scores for the American Urological Association (AUA) symptom index and benign prostatic hyperplasia (BPH) impact index with patient global ratings of improvement in a large Veterans Affairs trial comparing different pharmacological therapies for BPH.

MATERIALS AND METHODS

The primary analyses compared absolute score changes from baseline with global ratings of improvement at 13 weeks for 1,218 men.

RESULTS

Subjects who rated themselves as being slightly improved had a mean decrease in AUA symptom index and BPH impact index scores of 3.1 and 0.4 points, respectively. However, the baseline scores strongly influenced this relationship.

CONCLUSIONS

These data provide guidance for investigators using the AUA symptom index and BPH impact index as outcome measures.

摘要

目的

在一项比较不同药物治疗良性前列腺增生（BPH）的大型退伍军人事务部试验中，我们评估了美国泌尿外科学会（AUA）症状指数和BPH影响指数的得分变化与患者总体改善评分之间的关系。

材料与方法

主要分析比较了1218名男性从基线开始的绝对得分变化与13周时的总体改善评分。

结果

将自己评为稍有改善的受试者，其AUA症状指数和BPH影响指数得分平均分别下降3.1分和0.4分。然而，基线得分对这种关系有很大影响。

结论

这些数据为使用AUA症状指数和BPH影响指数作为结局指标的研究人员提供了指导。

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