Barry M J, Fowler F J, O'Leary M P, Bruskewitz R C, Holtgrewe H L, Mebust W K, Cockett A T
Medical Practices Evaluation Center, Massachusetts General Hospital, Boston.
J Urol. 1992 Nov;148(5):1549-57; discussion 1564. doi: 10.1016/s0022-5347(17)36966-5.
A symptom index for benign prostatic hyperplasia (BPH) was developed and validated by a multidisciplinary measurement committee of the American Urological Association (AUA). Validation studies were conducted involving a total of 210 BPH patients and 108 control subjects. The final AUA symptom index includes 7 questions covering frequency, nocturia, weak urinary stream, hesitancy, intermittence, incomplete emptying and urgency. On revalidation, the index was internally consistent (Cronbach's alpha = 0.86) and the score generated had excellent test-retest reliability (r = 0.92). Scores were highly correlated with subjects' global ratings of the magnitude of their urinary problem (r = 0.65 to 0.72) and powerfully discriminated between BPH and control subjects (receiver operating characteristic area 0.85). Finally, the index was sensitive to change, with preoperative scores decreasing from a mean of 17.6 to 7.1 by 4 weeks after prostatectomy (p < 0.001). The AUA symptom index is clinically sensible, reliable, valid and responsive. It is practical for use in practice and for inclusion in research protocols.
美国泌尿外科学会（AUA）的一个多学科测量委员会制定并验证了良性前列腺增生（BPH）症状指数。开展了涉及总共210例BPH患者和108例对照受试者的验证研究。最终的AUA症状指数包括7个问题，涵盖尿频、夜尿、尿流无力、排尿犹豫、尿流中断、排尿不尽和尿急。在重新验证时，该指数具有内部一致性（克朗巴哈系数α = 0.86），所产生的分数具有出色的重测信度（r = 0.92）。分数与受试者对其泌尿问题严重程度的总体评分高度相关（r = 0.65至0.72），并且能有效区分BPH患者和对照受试者（受试者工作特征曲线下面积为0.85）。最后，该指数对变化敏感，前列腺切除术后4周，术前分数从平均17.6降至7.1（p < 0.001）。AUA症状指数在临床上合理、可靠、有效且有反应性。它在临床实践中使用以及纳入研究方案都很实用。
