Bigatti M P, Lambert L, Crovella S, Ardito G
Dipartimento di Biologia Animale-Laboratori di Antropologia, Università di Torino, Italy.
Mutat Res. 1995 Aug;347(3-4):157-62. doi: 10.1016/0165-7992(95)00035-6.
Lymphocytes from chimeric individuals of the species Callithrix jacchus (Primates) were examined to evaluate differences in the frequency of sister chromatid exchanges (SCE) between XX and XY cells. The aim was to discover whether SCE differ according to genetic sex and whether XX and XY cells show a different sensitivity to SCE inducing agents. This experimental model has enabled us to eliminate the possible differences caused by environmental factors. The results obtained do not reveal significant differences between male and female cells, in either the baseline SCE frequency or that induced by mitomycin C at concentrations of 0.01 and 0.03 microgram/ml. No significant differences were observed in the distribution of high SCE frequency cells (HFC), even if it is possible to observe a higher level of exchanges in XX cells in each trial. With regard to the phenotypic sex, there appears to be a trend towards slightly higher SCE rates in females, even if results are not statistically significant.
对狨猴（灵长类动物）嵌合体个体的淋巴细胞进行了检查，以评估XX细胞和XY细胞之间姐妹染色单体交换（SCE）频率的差异。目的是发现SCE是否因遗传性别而异，以及XX和XY细胞对SCE诱导剂是否表现出不同的敏感性。这个实验模型使我们能够消除环境因素造成的可能差异。所获得的结果并未揭示在基线SCE频率或由浓度为0.01和0.03微克/毫升的丝裂霉素C诱导的SCE频率方面，雄性和雌性细胞之间存在显著差异。即使在每次试验中都可以观察到XX细胞中有较高水平的交换，但在高SCE频率细胞（HFC）的分布上未观察到显著差异。关于表型性别，即使结果在统计学上不显著，但似乎有女性SCE率略高的趋势。
