人类基因组的酵母人工染色体连续克隆系图谱。
A YAC contig map of the human genome.
作者信息
Chumakov I M, Rigault P, Le Gall I, Bellanné-Chantelot C, Billault A, Guillou S, Soularue P, Guasconi G, Poullier E, Gros I
机构信息
Fondation Jean Dausset Centre d'Etude du Polymorphisme Humain, Paris, France.
出版信息
Nature. 1995 Sep 28;377(6547 Suppl):175-297. doi: 10.1038/377175a0.
A yeast artificial chromosome library containing 33,000 clones with an average insert size of one megabase of human genomic DNA was extensively analysed by several different procedures for detecting overlaps and positional information. We developed an analysis strategy that resulted, after confirmatory tests, in a YAC contig map reliably covering about 75% of the human genome in 225 contigs having an average size of about ten megabases.
一个包含33000个克隆的酵母人工染色体文库，其人类基因组DNA平均插入片段大小为1兆碱基，通过几种不同的程序对其进行了广泛分析，以检测重叠和位置信息。我们开发了一种分析策略，经过验证性测试后，得到了一个酵母人工染色体重叠群图谱，该图谱可靠地覆盖了约75%的人类基因组，分布在225个重叠群中，平均大小约为10兆碱基。
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