Doggett N A, Goodwin L A, Tesmer J G, Meincke L J, Bruce D C, Clark L M, Altherr M R, Ford A A, Chi H C, Marrone B L
Center for Human Genome Studies, Los Alamos National Laboratory, New Mexico 87545, USA.
Nature. 1995 Sep 28;377(6547 Suppl):335-65. doi: 10.1038/377335a0.
We describe an integrated physical, genetic and cytogenetic map of human chromosome 16 comprising both a low-resolution megaYAC map and a high-resolution cosmid contig/miniYAC map, which provides nearly complete coverage of the euchromatic arms of the chromosome. The physical map is anchored to a high-resolution cytogenetic breakpoint map and is integrated with genetic and gene transcript maps of the chromosome by sequence-tagged sites and clone hybridizations.
我们描述了人类16号染色体的综合物理、遗传和细胞遗传图谱，其中包括一个低分辨率的大酵母人工染色体（megaYAC）图谱和一个高分辨率的黏粒重叠群/微型酵母人工染色体（miniYAC）图谱，该图谱几乎覆盖了该染色体常染色质臂的全部区域。该物理图谱以高分辨率细胞遗传断点图谱为锚定，并通过序列标签位点和克隆杂交与该染色体的遗传图谱和基因转录图谱整合在一起。
