覆盖人类8号染色体25厘摩的综合物理图谱。
An integrated physical map covering 25 cM of human chromosome 8.
作者信息
Chen W, Hou J, Wagner M J, Wells D E
机构信息
Department of Biology, University of Houston, Texas 77204, USA.
出版信息
Genomics. 1996 Feb 15;32(1):117-20. doi: 10.1006/geno.1996.0084.
We have developed an integrated physical map for human chromosome 8q23-q24.1 based on STS content analysis of somatic cell hybrids and YAC contigs. Among the 63 STSs used are markers from multiple genetic maps and several previously unmapped polymorphisms, thus integrating genetic markers from different sources into comprehensive, ordered sets based on their positions in the physical map. These maps will facilitate the isolation of genes causing human inherited diseases that map to these chromosomal regions.
我们基于对体细胞杂种和酵母人工染色体（YAC）重叠群的序列标签位点（STS）含量分析，构建了人类8号染色体q23 - q24.1区域的综合物理图谱。所使用的63个STS中，有来自多个遗传图谱的标记以及几个先前未定位的多态性标记，从而根据它们在物理图谱中的位置，将来自不同来源的遗传标记整合为全面、有序的集合。这些图谱将有助于分离定位于这些染色体区域的导致人类遗传性疾病的基因。
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