van Gool J, Ladiges N C, de Nie I, Boers W
Agents Actions Suppl. 1977;2:149-61. doi: 10.1007/978-3-0348-7177-8_13.
alphaMFoetoprotein of the rat (rat alpha2macroglobulin) is present in serum during foetal development. After birth, alphaMFP declines rapidly, but the protein returns after injury. The injury we used consisted of skin and muscle incision, laparotomy, BaSO4 i.p. The protein occurs also during liverregeneration, livercardinogenesis en during infections. Therefore, alphaMFP can be considered as an acute phase reactant. We found that this protein strongly inhibits inflammatory exudation caused by carrageenin, histamin, prostaglandin E2, 5HT and bradykinin. Furthermore, we found that alphaMFP suppresses completely inflammatory reactions during Ga1.N-hepatitis. In this condition, the primary biochemical lesion, consisting of liver UDPG depletion, does occur in spite of the protective effect of alphaMFP. Thus, the inflammatory inhibiting effects of alphaMFP seem to be an important mechanism reducing inflammatory reaction patterns.
大鼠的α甲胎蛋白（大鼠α2巨球蛋白）在胎儿发育期间存在于血清中。出生后，α甲胎蛋白迅速下降，但在受伤后该蛋白会再度出现。我们所采用的损伤包括皮肤和肌肉切开、剖腹术、腹腔注射硫酸钡。该蛋白在肝脏再生、肝心生成以及感染期间也会出现。因此，α甲胎蛋白可被视为一种急性期反应物。我们发现这种蛋白能强烈抑制角叉菜胶、组胺、前列腺素E2、5-羟色胺和缓激肽所引发的炎症渗出。此外，我们发现α甲胎蛋白能完全抑制半乳糖胺性肝炎期间的炎症反应。在这种情况下，尽管有α甲胎蛋白的保护作用，由肝脏尿苷二磷酸葡萄糖耗竭构成的原发性生化损伤仍会发生。因此，α甲胎蛋白的炎症抑制作用似乎是减轻炎症反应模式的一种重要机制。
