Stratta R J, Taylor R J, Larsen J L, Cushing K
Department of Surgery, University of Nebraska Medical Center, Omaha 68198-3280, USA.
Ren Fail. 1995 Jul;17(4):323-37. doi: 10.3109/08860229509037599.
Vascularized pancreas transplantation has assumed an increasing role in the treatment of diabetes mellitus. Through 1994, over 6000 pancreas transplants had been performed worldwide, with over 80% being combined pancreas-kidney transplants. Overall 1-year patient survival exceeds 90% and graft survival (complete insulin independence) exceeds 70%. Although successful pancreas transplantation achieves euglycemia and complete insulin independence, this occurs at the expense of hyperinsulinemia and chronic immunosuppression. The net effect of these changes on diabetic complications in the long term remains to be determined. In the short term, improvement in the quality of life and possible prevention of further morbidity associated with diabetes makes pancreas transplantation an important therapeutic option, particularly when combined with a kidney transplant, in appropriately selected diabetic patients.
血管化胰腺移植在糖尿病治疗中发挥着越来越重要的作用。截至1994年，全球已进行了6000多例胰腺移植，其中超过80%为胰腺-肾脏联合移植。总体而言，患者1年生存率超过90%，移植物生存率（完全脱离胰岛素）超过70%。虽然成功的胰腺移植可实现血糖正常和完全脱离胰岛素，但这是以高胰岛素血症和长期免疫抑制为代价的。这些变化对糖尿病并发症的长期净效应仍有待确定。短期内，生活质量的改善以及可能预防与糖尿病相关的进一步发病，使得胰腺移植成为一种重要的治疗选择，特别是在适当选择的糖尿病患者中与肾脏移植联合进行时。
