Wållberg-Jonsson S, Uddhammar A, Dahlén G, Rantapää-Dahlqvist S
Department of Rheumatology, University Hospital, Umeå, Sweden.
Scand J Clin Lab Invest. 1995 Jul;55(4):309-15. doi: 10.3109/00365519509104968.
The effect of altered inflammatory activity, as reflected by acute phase protein levels, on the concentration of lipoprotein(a) was analysed in 51 patients with rheumatoid arthritis (RA), and in 25 patients with polymyalgia rheumatica (PMR). Despite significantly decreased acute phase proteins in RA, the Lp(a) concentration increased significantly between the two observations in the group as a whole. In one subgroup with initially high Lp(a) levels, large intraindividual variations between the samplings and a high correlation to the ESR changes were found. Another subgroup with initially low levels showed small variations of Lp(a) without correlation to any acute phase reactant. In the PMR group, Lp(a) decreased in line with diminishing acute phase reactivity.
在51例类风湿关节炎（RA）患者和25例风湿性多肌痛（PMR）患者中，分析了由急性期蛋白水平反映的炎症活动改变对脂蛋白（a）浓度的影响。尽管RA患者的急性期蛋白显著降低，但在整个组的两次观察之间，Lp（a）浓度显著升高。在一个初始Lp（a）水平较高的亚组中，发现两次采样之间个体内差异很大，且与血沉变化高度相关。另一个初始水平较低的亚组显示Lp（a）变化较小，与任何急性期反应物均无相关性。在PMR组中，Lp（a）随急性期反应性降低而下降。
