Albuquerque M F, Marzochi M C, Sabroza P C, Braga M C, Padilha T, Silva M C, Silva M R, Schindler H C, Maciel M A, Souza W
Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, Universidade Federal de Pernambuco, Recifè, Brazil.
Trans R Soc Trop Med Hyg. 1995 Jul-Aug;89(4):373-7. doi: 10.1016/0035-9203(95)90014-4.
Bancroftian filariasis is a major public health problem in the city of Recife in north-eastern Brazil. In some of its urban areas microfilaraemia prevalence reaches 14%. This study describes epidemiological characteristics, infection and disease, in 2 urban areas, Coque and Mustardinha, before control measures were applied. The parasitological survey was performed by a 'door-to-door' census covering 5563 subjects, aged between 5 and 65 years. Microfilaraemia was detected by the thick drop technique, using 45 microL of peripheral blood collected between 20:00 and 24:00. In both areas the prevalence of microfilaraemia was 10%, and males had higher prevalences of infection and disease than females. The prevalence of microfilaraemia was higher in the 15-24 and 25-34 years age groups in both sexes. Most microfilaria (mf) carriers (72.1% in Coque and 79.7% in Mustadrinha) had mf densities < 100/60 microL of blood. Females of reproductive age had significantly lower mf densities than males. The overall disease prevalence in both areas was 6.3%. Amongst the subjects who presented with chronic disease 15.7% were microfilaraemic. Chronic disease prevalence increased from 1.4% in the 5-14 years age group to 11.3% in the oldest age group. The most frequent clinical manifestation was hydrocele (5.4%), followed by lymphoedema (1.8%). The epidemiological pattern of filariasis in the populations studied was marked by high prevalence of microfilaraemia, low mf density, and relatively low prevalence of filarial disease considering the level of endemicity.
班氏丝虫病是巴西东北部累西腓市的一个主要公共卫生问题。在该市一些城区，微丝蚴血症患病率高达14%。本研究描述了在采取控制措施之前，科克和穆斯塔尔迪尼亚这两个城区的流行病学特征、感染情况和疾病情况。寄生虫学调查通过“挨家挨户”普查进行，涵盖5563名年龄在5至65岁之间的受试者。采用厚血滴技术检测微丝蚴血症，使用在20:00至24:00采集的45微升外周血。在这两个地区，微丝蚴血症患病率均为10%，男性的感染率和疾病患病率高于女性。在15 - 24岁和25 - 34岁年龄组中，两性的微丝蚴血症患病率均较高。大多数微丝蚴携带者（科克地区为72.1%，穆斯塔尔迪尼亚地区为79.7%）的微丝蚴密度<100/60微升血液。育龄女性的微丝蚴密度显著低于男性。两个地区的总体疾病患病率为6.3%。在患有慢性病的受试者中，15.7%为微丝蚴血症患者。慢性病患病率从5 - 14岁年龄组的1.4%增至最高年龄组的11.3%。最常见的临床表现是鞘膜积液（5.4%），其次是淋巴水肿（1.8%）。在所研究人群中，丝虫病的流行病学模式特点是微丝蚴血症患病率高、微丝蚴密度低，且考虑到地方流行程度，丝虫病患病率相对较低。
