Deltenre P, Ghilain J M, Maisin J M, Schapira M, Henrion J, Heller F R
Service de Médecine Interne, Hôpital de Jolimont, Haine St Paul, Belgique.
Acta Gastroenterol Belg. 1995 Mar-Apr;58(2):222-9.
Early distinction between acute alcoholic pancreatitis is important, because of possible emergency endoscopic sphincterotomy in case of biliary pancreatitis. The aim of this study was to evaluate the value of L/A ratio in the diagnosis of acute alcoholic pancreatitis. From 1990 to end 1993, 133 patients with acute pancreatitis were reviewed. Inclusion criteria were: 1) abdominal pain, 2) pathological serum amylase or serum lipase on admission or within 24 hours after beginning or abdominal pain, 3) acute pancreatitis at the echography or CT scan within 48 hours after admission. 60 patients met the inclusion criteria (31 alcoholic pancreatitis, 19 biliary pancreatitis and 10 pancreatitis of other causes). L/A ratio was studied in terms of delay from beginning of abdominal pain. There was no statistical difference between alcoholic and biliary pancreatitis at any time of the study, with the exception of admission. AST, ALT and alkaline phosphatase were higher in biliary pancreatitis than in alcoholic pancreatitis. AST and ALT were the best biochemical tests to diagnose biliary pancreatitis. Blamey's criteria can also contribute to diagnose biliary pancreatitis. These biochemical tests are the most helpful if they are collected very soon in the evolution of acute pancreatitis. It is concluded that L/A ratio is not helpful in the diagnosis of alcoholic acute pancreatitis.
早期区分急性酒精性胰腺炎很重要,因为对于胆源性胰腺炎可能需要紧急进行内镜括约肌切开术。本研究的目的是评估L/A比值在诊断急性酒精性胰腺炎中的价值。对1990年至1993年底的133例急性胰腺炎患者进行了回顾性研究。纳入标准为:1)腹痛;2)入院时或腹痛开始后24小时内血清淀粉酶或血清脂肪酶异常;3)入院后48小时内超声或CT扫描显示为急性胰腺炎。60例患者符合纳入标准(31例酒精性胰腺炎,19例胆源性胰腺炎,10例其他原因引起的胰腺炎)。根据腹痛开始后的时间来研究L/A比值。除入院时外,在研究的任何时间,酒精性胰腺炎和胆源性胰腺炎之间均无统计学差异。胆源性胰腺炎患者的谷草转氨酶(AST)、谷丙转氨酶(ALT)和碱性磷酸酶高于酒精性胰腺炎患者。AST和ALT是诊断胆源性胰腺炎的最佳生化指标。布莱梅标准也有助于诊断胆源性胰腺炎。如果在急性胰腺炎病程中尽早进行这些生化检测,它们将最有帮助。结论是L/A比值对酒精性急性胰腺炎的诊断没有帮助。