Uchihara T, Kondo H, Akiyama H, Ikeda K
Department of Neurology, Faculty of Medicine, Tokyo Medical and Dental University, Japan.
Acta Neuropathol. 1995;90(1):51-6. doi: 10.1007/BF00294459.
Amyloid beta-protein (A beta) deposits in the white matter were investigated by the double immunohistochemical staining for A beta and neuritic, glial or vascular components. Reactive astroglia and neurite abnormality were absent around A beta deposits in the white matter (w-A beta) even those with a core. The association of w-A beta with blood vessels was not consistent. Aggregates of activated microglia were found to be the sole but a consistent accompaniment of A beta deposits even in the absence of other components such as neuron, synapse, neurite abnormality and reactive astroglia, as observed in the white matter. This suggests that the aggregates of activated microglia most likely represent one of the factors promoting the process of A beta deposition.
通过对β淀粉样蛋白（Aβ）与神经突、神经胶质或血管成分进行双重免疫组织化学染色，研究了白质中Aβ的沉积情况。即使是有核心的白质Aβ（w-Aβ）沉积物周围也未出现反应性星形胶质细胞和神经突异常。w-Aβ与血管的关联并不一致。研究发现，即使在没有神经元、突触、神经突异常和反应性星形胶质细胞等其他成分的情况下，活化小胶质细胞聚集体也是Aβ沉积物唯一且始终伴随的成分，如在白质中观察到的那样。这表明活化小胶质细胞聚集体很可能是促进Aβ沉积过程的因素之一。
