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儿童癌症与父亲暴露于电离辐射:牛津儿童癌症调查的第二篇报告

Childhood cancer and paternal exposure to ionizing radiation: a second report from the Oxford Survey of Childhood Cancers.

作者信息

Sorahan T, Lancashire R J, Temperton D H, Heighway W P

机构信息

Institute of Occupational Health, University of Birmingham, Edgbaston, UK.

出版信息

Am J Ind Med. 1995 Jul;28(1):71-8. doi: 10.1002/ajim.4700280106.

DOI:10.1002/ajim.4700280106
PMID:7573076
Abstract

Paternal occupational data already collected as part of the Oxford Survey of Childhood Cancers have been reviewed. Information on paternal occupation was available for 14,869 children dying from cancer in England, Wales, and Scotland in the period 1953-81 and for an equal number of matched controls. The importance of fathers working, at any time before or after conception of the survey child, in any of the following occupations was assessed: radiologists (clinical), surgeons and anesthetists, veterinary surgeons, dental surgeons, nuclear industry workers, industrial radiographers. There was no indication that preconception employment in any of these occupations was more important than postconception employment with regard to the risks of all childhood cancers or all childhood leukemias. Findings were consistent with neither paternal preconception exposure to external ionizing radiation nor exposure to unsealed sources of radionuclides being an important risk factor for childhood leukemia or for the overall grouping of all childhood cancers.

摘要

作为牛津儿童癌症调查的一部分,已经收集的父亲职业数据已被审查。在1953年至1981年期间,有14869名在英格兰、威尔士和苏格兰死于癌症的儿童以及数量相等的匹配对照的父亲职业信息。评估了父亲在调查对象受孕之前或之后的任何时间从事以下任何职业的重要性:放射科医生(临床)、外科医生和麻醉师、兽医、牙科医生、核工业工人、工业放射技师。没有迹象表明,就所有儿童癌症或所有儿童白血病的风险而言,受孕前从事这些职业中的任何一种比受孕后从事这些职业更重要。研究结果与父亲受孕前暴露于外部电离辐射或暴露于放射性核素的非密封源均不是儿童白血病或所有儿童癌症总体分组的重要危险因素这一观点一致。

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