Sorahan T, Roberts P J
Department of Public Health and Epidemiology, University of Birmingham, Edgbaston, UK.
Am J Ind Med. 1993 Feb;23(2):343-54. doi: 10.1002/ajim.4700230211.
Paternal occupational data already collected as part of the Oxford Survey of Childhood Cancers have been reviewed. Information on occupations during or before the relevant pregnancy was sought for 15,279 children dying from cancer in England, Wales, and Scotland in the period 1953-81, and for an equal number of matched controls. Estimates were made for paternal exposure to human-made external ionizing radiation in the six months before conception of the survey child--as judged from job histories and dates of birth. Assessments were also made for potential exposure to unsealed sources of radionuclides. Of the eight fathers placed in the highest dose group (> or = 10 mSv, external radiation), four were cases and four were controls. For the second dose group (5-9 mSv), the corresponding numbers were eight and four, and for the lowest exposed group (1-4 mSv), they were 55 and 42. There were 27 case fathers with potential exposure to radionuclides and only 10 control fathers. The independent effects of the two radiation variables were assessed by means of multiple logistic regression. Relative risks for estimated doses of external radiation were close to unity, but for radionuclide exposure the relative risk was 2.87 (95% CI = 1.15-7.13). These preliminary findings suggest that paternal exposure to radionuclides is a more likely risk factor for childhood cancer than exposure to external radiation.
已对作为牛津儿童癌症调查一部分而收集的父亲职业数据进行了审查。我们收集了1953年至1981年期间在英格兰、威尔士和苏格兰死于癌症的15279名儿童以及数量与之相等的匹配对照儿童的相关孕期或孕前职业信息。根据工作经历和调查对象的出生日期，估算了父亲在调查对象受孕前六个月接触人工外部电离辐射的情况。还对接触放射性核素非密封源的潜在情况进行了评估。在被归入最高剂量组（≥10毫希沃特，外部辐射）的8名父亲中，4名是病例组，4名是对照组。对于第二剂量组（5 - 9毫希沃特），相应数字分别为8名和4名，而对于最低暴露组（1 - 4毫希沃特），分别为55名和42名。有27名病例组父亲有接触放射性核素的潜在可能，而对照组父亲只有10名。通过多因素逻辑回归评估了这两个辐射变量的独立影响。外部辐射估计剂量的相对风险接近1，但对于放射性核素暴露，相对风险为2.87（95%置信区间 = 1.15 - 7.13）。这些初步研究结果表明，父亲接触放射性核素比接触外部辐射更有可能是儿童癌症的风险因素。
