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多发性硬化症(MS)的诊断问题:两项特定的实验室检查。

The diagnostic problem in multiple sclerosis (M.S.): two specific laboratory tests.

作者信息

Field E J

出版信息

Boll Ist Sieroter Milan. 1978 Jan 31;56(6):552-6.

PMID:75734
Abstract

In the present paper are discussed the diagnostic problems in M.S., there has been difficulty in certain diagnostic on the first modest signs in a proportion perhaps as high as 20% and the absence of a specific and reliable laboratory test has long been felt. This study describes two specific laboratory tests in M.S. The MEM-LAD test (macrophage electrophoretic mobility linoleic acid depression) and the E-UFA test (erythrocyte-unsaturated fatty acid). It may be noted that whilst the E-UFA and MEM-LAD test will diagnose (or esclude) M.S. the former is simpler, but is limited to M.S., the latter on the other hand once mastered is applicable in the whole range of clinical immunology were lymphocyte sensitisation is to be measured.

摘要

本文讨论了多发性硬化症(M.S.)的诊断问题,对于某些最初症状轻微的病例,诊断存在困难,比例可能高达20%,而且长期以来一直感到缺乏一种特异且可靠的实验室检测方法。本研究描述了两种用于多发性硬化症的特异性实验室检测方法。即MEM-LAD检测(巨噬细胞电泳迁移率亚油酸降低)和E-UFA检测(红细胞不饱和脂肪酸)。需要注意的是,虽然E-UFA检测和MEM-LAD检测都可用于诊断(或排除)多发性硬化症,但前者更简单,不过仅限于多发性硬化症,而后者一旦掌握,可应用于整个临床免疫学领域,用于测量淋巴细胞致敏情况。

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