用于淋巴细胞致敏的巨噬细胞电泳迁移（MEM）试验。动力学研究。
The macrophage electrophoretic migration (MEM) test for lymphocyte sensitization. A study of the kinetics.
作者信息
Carnegie P R, Caspary E A, Dickinson J P, Field E J
出版信息
Clin Exp Immunol. 1973 May;14(1):37-45.
Abstract
The macrophage electrophoretic migration (MEM) test for lymphocyte sensitization (Field & Caspary, 1971; Caspary & Field, 1971) has been used to study a number of problems (reviewed by Field, 1972) and seems widely applicable in clincial immunology. Whilst the conditions of the test have been established empirically and it is known to involve protein synthesis by both lymphocytes (Caspary, 1971) and the indicator macrophages (Caspary, 1972) the kinetics of the test have not previously been investigated. Some observations of the effects of variation in antigen dosage and in number of lymphocytes employed, `avidity' of antigen and dilution of macrophage slowing factor (MSF) are here presented.
摘要
用于淋巴细胞致敏的巨噬细胞电泳迁移（MEM）试验（菲尔德和卡斯帕里，1971年；卡斯帕里和菲尔德，1971年）已被用于研究许多问题（菲尔德综述，1972年），并且似乎在临床免疫学中广泛适用。虽然该试验的条件是通过经验确定的，并且已知其涉及淋巴细胞（卡斯帕里，1971年）和指示巨噬细胞（卡斯帕里，1972年）的蛋白质合成，但该试验的动力学以前尚未研究过。本文介绍了关于抗原剂量变化、所用淋巴细胞数量、抗原“亲和力”以及巨噬细胞趋化因子（MSF）稀释的一些观察结果。
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本文引用的文献
1
AN ENCEPHALITOGENIC PROTEIN OF HUMAN ORIGIN: SOME CHEMICAL AND BIOLOGICAL PROPERTIES.一种人类源致脑炎蛋白：一些化学和生物学特性
Ann N Y Acad Sci. 1965 Mar 31;122:182-98. doi: 10.1111/j.1749-6632.1965.tb20202.x.
2
3
SEPARATION OF VIABLE LYMPHOCYTES FROM HUMAN BLOOD.从人血中分离活淋巴细胞
Lancet. 1964 Feb 29;1(7331):468-9. doi: 10.1016/s0140-6736(64)90799-8.
4
5
Functional anatomy of the lymphocyte in immunological reactions in vitro.淋巴细胞在体外免疫反应中的功能解剖学
J Exp Med. 1966 Nov 1;124(5):851-8. doi: 10.1084/jem.124.5.851.
6
Demonstration of sensitized lymphocytes in blood.血液中致敏淋巴细胞的检测
J Clin Pathol. 1971 Mar;24(2):179-81. doi: 10.1136/jcp.24.2.179.
7
Lymphocyte transformation in vitro measured by tritiated thymidine uptake. I. Lymphocyte culture techniques.通过氚标记胸腺嘧啶核苷摄取法体外测定淋巴细胞转化。I. 淋巴细胞培养技术。
Int Arch Allergy Appl Immunol. 1970;37(5):506-31. doi: 10.1159/000230240.
8
Lymphocyte sensitization in advanced malignant disease: a study of serum lymphocyte depressive factor.晚期恶性疾病中的淋巴细胞致敏作用：血清淋巴细胞抑制因子的研究
Br J Cancer. 1972 Jun;26(3):164-73. doi: 10.1038/bjc.1972.23.
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Clin Exp Immunol. 1972 Jun;11(2):305-9.
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