Field E J, Shenton B K, Joyce G
Br Med J. 1974 Mar 9;1(5905):412-4. doi: 10.1136/bmj.1.5905.412.
Lymphocytes from patients with multiple sclerosis are much more susceptible to the inhibitory activity of linoleic acid (0.08 mg/ml) when tested for sensitization to thyroid by the macrophage electrophoretic mobility test (91% inhibition) than are those from normal subjects (57% inhibition). Cells from patients with a variety of other neurological diseases give 47% inhibition with linoleic acid. These differences are specific for multiple sclerosis and can be used as an in-vitro diagnostic test for the disease. Nearly 43% of clinically normal near relatives of patients with multiple sclerosis show an "anomalous" figure of about 77%; in the remainder the figure is the same as in the general population (57%). An anomalous result is compatible with lifelong freedom from M.S. Possibly a congenital anomalous handling of unsaturated fatty acids is a constant feature of the disease.
当通过巨噬细胞电泳迁移率试验检测对甲状腺的致敏性时，与正常受试者的淋巴细胞（抑制率57%）相比，多发性硬化症患者的淋巴细胞对亚油酸（0.08毫克/毫升）的抑制活性更为敏感（抑制率91%）。患有多种其他神经系统疾病的患者的细胞，亚油酸的抑制率为47%。这些差异是多发性硬化症所特有的，可作为该疾病的体外诊断试验。多发性硬化症患者中近43%临床上正常的近亲显示出约77%的“异常”数值；其余的数值与普通人群相同（57%）。异常结果与终身不患多发性硬化症相符。可能对不饱和脂肪酸的先天性异常处理是该疾病的一个恒定特征。
