Field E J, Caspary E A, Smith K S
Br J Cancer Suppl. 1973 Aug;1:208-14.
Of 464 patients with verified cancer tested, 463 have been correctly diagnosed by measuring their lymphocyte sensitization to encephalitogenic factor or cancer basic protein. One patient with very rapidly advancing cancer gave a negative result but was found to have marked general hyporeactivity of her lymphocytes of unknown cause. Leukaemia, advanced tuberculosis, asthma, sarcoidosis, systemic lupus erythematosus, and a number of rare conditions may interfere with a correct diagnosis. It is advisable to test guinea-pigs for spontaneous sensitization to encephalitogenic factor and to exclude some of the other conditions by testing for sensitization of the patient's lymphocytes to BSA and PPD.
在464例经证实患有癌症的患者中进行检测,通过测量其淋巴细胞对致脑炎因子或癌基础蛋白的敏感性,463例得到了正确诊断。1例癌症进展非常迅速的患者检测结果为阴性,但发现其淋巴细胞普遍存在明显的反应性低下,原因不明。白血病、晚期肺结核、哮喘、结节病、系统性红斑狼疮以及一些罕见病症可能会干扰正确诊断。建议检测豚鼠对致脑炎因子的自发敏感性,并通过检测患者淋巴细胞对牛血清白蛋白(BSA)和结核菌素纯蛋白衍生物(PPD)的敏感性来排除其他一些病症。