Murphy S, Watkins W M, Bray P G, Lowe B, Winstanley P A, Peshu N, Marsh K
Kenya Medical Research Institute, Kilifi Research Unit.
Am J Trop Med Hyg. 1995 Sep;53(3):303-5. doi: 10.4269/ajtmh.1995.53.303.
The effect of artemether (AR) and quinine (QN) on parasite viability ex vivo was compared in children being treated for severe Plasmodium falciparum malaria. Parasitized blood taken at intervals during treatment was cultured in vitro, and parasite development was assessed microscopically. Parasite viability (defined as the proportion of circulating rings developing to early schizonts) was 56.8% in the AR group (n = 7) 6 hr after the start of treatment, compared with 93.3% for QN (n = 6; P = 0.015). Even after 24 hr of QN treatment, parasite viability was not significantly reduced in five patients. These ex vivo findings, which confirm previous observations of the stage-specific effects of these drugs against P. falciparum, suggest that AR may be superior to QN in the treatment of severe malaria.
在接受重症恶性疟原虫疟疾治疗的儿童中，比较了蒿甲醚（AR）和奎宁（QN）对体外寄生虫活力的影响。在治疗期间每隔一段时间采集的带虫血液进行体外培养，并通过显微镜评估寄生虫发育情况。治疗开始6小时后，AR组（n = 7）的寄生虫活力（定义为循环中的环状体发育为早期裂殖体的比例）为56.8%，而QN组（n = 6；P = 0.015）为93.3%。即使经过24小时的QN治疗，5名患者的寄生虫活力也没有显著降低。这些体外研究结果证实了之前关于这些药物对恶性疟原虫阶段特异性作用的观察结果，表明在重症疟疾治疗中，AR可能优于QN。
