齐多夫定磷酸化的体外药物相互作用。
Drug interactions with zidovudine phosphorylation in vitro.
作者信息
Hoggard P G, Veal G J, Wild M J, Barry M G, Back D J
机构信息
Department of Pharmacology & Therapeutics, University of Liverpool, United Kingdom.
出版信息
Antimicrob Agents Chemother. 1995 Jun;39(6):1376-8. doi: 10.1128/AAC.39.6.1376.
Abstract
We have investigated the effect of a range of drugs (some commonly coadministered with zidovudine [ZDV] to human immunodeficiency virus-positive patients) on intracellular phosphorylation of ZDV by stimulated peripheral blood mononuclear cells, Molt 4 cells, and U937 cells in vitro. Of the drugs tested (azoles, antiviral agents, antibiotics, and anticancer agents), only doxorubicin and ribavirin caused inhibition of anabolite formation as measured by high-performance liquid chromatography. This in vitro approach may provide important leads to potential interactions at the phosphorylation level in patients with human immunodeficiency virus disease. It is reassuring that so many commonly administered drugs do not alter ZDV phosphorylation.
摘要
我们已经研究了一系列药物（其中一些常与齐多夫定 [ZDV] 联合用于人类免疫缺陷病毒阳性患者）对体外刺激的外周血单核细胞、Molt 4 细胞和 U937 细胞中 ZDV 细胞内磷酸化的影响。在所测试的药物（唑类、抗病毒剂、抗生素和抗癌剂）中，只有阿霉素和利巴韦林通过高效液相色谱法测定导致代谢物形成受到抑制。这种体外方法可能为人类免疫缺陷病毒疾病患者磷酸化水平的潜在相互作用提供重要线索。令人放心的是，如此多常用药物不会改变 ZDV 的磷酸化。
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