Wirth H, Vollweiler B, Gloor M, Schnyder U W
Arch Dermatol Res. 1978;263(1):31-5.
The thymidine labelling index and the mitosis rate (blocked by colcemid) in the basal cell layer of the guinea pig were determined before and during treatment with 5-fluorouracil (1 mg i.p. in 2 day's interval/100 g body weight). Additionally, the epidermal area and thickness and the number and size of cells were measured. 5-Fluorouracil equally reduces the thymidine labelling index and the mitosis rate with the full effect after treatment of at least 22 days. From these findings it is concluded that the S-phase--calculated from the end of the thymidine synthesis--is not altered. Furthermore atrophy of the epidermis runs parallel with the reduction of the 3H thymidine labelling index and the mitosis rate.
在用5-氟尿嘧啶（每100克体重腹腔注射1毫克，间隔2天给药）治疗前及治疗期间，测定豚鼠基底细胞层的胸苷标记指数和有丝分裂率（用秋水仙酰胺阻断）。此外，还测量了表皮面积、厚度以及细胞数量和大小。5-氟尿嘧啶同等程度地降低胸苷标记指数和有丝分裂率，至少治疗22天后达到完全效果。从这些发现可以得出结论，从胸苷合成结束计算的S期没有改变。此外，表皮萎缩与3H胸苷标记指数和有丝分裂率的降低平行。
