Kono Takahiro, Imanishi Nobuaki, Nozawa Keiko, Takashima Atsuo, Maheswari Rajagopalan Uma, Gonome Hiroki, Yamada Jun
Shibaura Institute of Technology, 3-7-5 Toyosu, Koto-ku, Tokyo, 135-8548, Japan.
Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Biomed Opt Express. 2019 Jul 2;10(8):3747-3759. doi: 10.1364/BOE.10.003747. eCollection 2019 Aug 1.
The fluorinated pyrimidine anticancer agent has several side effects that degrade the quality of life of patients, including hyperpigmentation. Hyperpigmentation differs in color from common pigmentation such as a suntan, giving rise to dramatic skin appearance changes. In this study, we measured the optical properties of the skin of patients with hyperpigmentation by using the reflection spatial profile method (RSPM). The absorption coefficient in hyperpigmentation increased ~1.5-2.5 times and pheomelanin significantly increased compared to the normal skin. In addition, the scattering coefficient of skin with hyperpigmentation was about 65.9-76.5% of that of normal skin.
氟嘧啶类抗癌药有多种会降低患者生活质量的副作用，包括色素沉着过度。色素沉着过度在颜色上与常见的色素沉着（如晒黑）不同，会导致皮肤外观发生显著变化。在本研究中，我们使用反射空间轮廓法（RSPM）测量了色素沉着过度患者皮肤的光学特性。与正常皮肤相比，色素沉着过度部位的吸收系数增加了约1.5至2.5倍，且褐黑素显著增加。此外，色素沉着过度皮肤的散射系数约为正常皮肤的65.9%至76.5%。
