Heine R G, Jaquiery A, Lubitz L, Cameron D J, Catto-Smith A G
Royal Children's Hospital, Melbourne, Australia, Department of Gastroenterology.
Arch Dis Child. 1995 Aug;73(2):121-5. doi: 10.1136/adc.73.2.121.
Gastro-oesophageal reflux (GOR) disease may cause excessive crying in infants. The role of GOR was evaluated in infant irritability and an attempt was made to define clinical predictors of pathological reflux. Seventy consecutively admitted infants with irritability and presumptive GOR were retrospectively reviewed. All had undergone prolonged oesophageal pH monitoring. Pathological GOR was defined as a fractional reflux time of > or = 10% and was significantly less common in infants under 3 months (one of 24; 4.2%) than in older infants (10 of 46; 21.7%). All infants with pathological GOR presented with frequent vomiting, and 'silent' pathological reflux did not occur. Poor weight gain, feeding refusal, backarching, and sleep disturbance were not significantly associated with pathological GOR. The results suggest that pathological GOR is an unlikely cause of infant irritability under the age of 3 months.
胃食管反流（GOR）病可能导致婴儿过度哭闹。对GOR在婴儿易激惹中的作用进行了评估，并试图确定病理性反流的临床预测因素。对70例连续入院的易激惹且疑似GOR的婴儿进行了回顾性研究。所有婴儿均接受了长时间的食管pH监测。病理性GOR定义为反流时间分数>或=10%，在3个月以下婴儿中（24例中的1例；4.2%）明显比大龄婴儿（46例中的10例；21.7%）少见。所有病理性GOR婴儿均有频繁呕吐，未发生“沉默性”病理性反流。体重增加不佳、拒食、反弓和睡眠障碍与病理性GOR无显著相关性。结果表明，病理性GOR不太可能是3个月以下婴儿易激惹的原因。
