Comparison of cardiac output measurements by thermodilution and thoracic electrical bioimpedance in critically ill versus non-critically ill patients.

Thoracic electrical bioimpedance (TEB) has been proposed as an alternative to thermodilution (TD) for the measurement of cardiac output in settings such as the Emergency Department where invasive monitoring is not available. Validation studies comparing TEB with TD suggest a wide range of variability in the agreement between the two methods. This prospective study tests the hypothesis that this variability may be related to the severity of patient illness. Fifteen non-critically ill patients undergoing cardiac catheterization and 13 critically ill patients who underwent Swan-Ganz catheterization in the medical intensive care unit (MICU) were enrolled. Fifty-one pairs of data from the catheterization laboratory and 49 pairs of data from the MICU were obtained. The patients were graded retrospectively according to the APACHE II scoring system. The mean difference (bias) between TEB and TD results was calculated for each patient using the method suggested by Bland and Altman. A pooled t-test was performed to determine whether there was any significant difference between the APACHE II scores or cardiac output measurements obtained by TEB and TD in the two groups. APACHE II scores were 4.7 +/- 1.2 for the catheterization laboratory and 14.2 +/- 5.0 for the intensive care unit patients (P < .001). The catheterization laboratory (cath lab) group bias was 0.23 +/- 2.19, whereas the MICU bias was .002 +/- 2.33. There was no significant difference in the bias between the two groups despite significant differences in the APACHE II scores. Standard deviations of the bias were less than 15% different from each other.(ABSTRACT TRUNCATED AT 250 WORDS)