Tromovitch T A, Stegman S J
Cancer. 1978 Feb;41(2):653-8. doi: 10.1002/1097-0142(197802)41:2<653::aid-cncr2820410232>3.0.co;2-x.
A modification of Mohs' chemosurgery which eliminates the zinc chloride paste but follows the careful piece by piece excision, marking, and mapping has been developed for the treatment of cutaneous tumors. The technique is called Microscopic Controlled Exicision (MCE). This 8-year retrospective study reports a 97.2% cure rate for 532 determinant lesions. On hundred eighty-five (35%) of these cases followed for 5 years or longer had a 96% cure rate. The modified technique eliminates the pain of zinc chloride fixative paste, shortens the time required to perform the surgery, removes less uninvolved, normal tissues, and the final defect is a fresh surgical wound which can be repaired immediately. These advantages become highly significant since a high 5-year cure rate can be obtained. It is recommended that this technique be used for all tumors which recur after routine treatment by excision, radiation therapy, curettage and desiccation, or cryosurgery, for tumors with poorly defined clinical borders, for sclerosing basal cell epitheliomas, and for primary cutaneous carcinomas in areas which have a predilection for recurrence.
已开发出一种改良的莫氏化学外科手术方法,该方法省去了氯化锌糊剂,但遵循逐块仔细切除、标记和绘图的步骤,用于治疗皮肤肿瘤。这种技术被称为显微镜控制切除(MCE)。这项为期8年的回顾性研究报告称,532例确定性病变的治愈率为97.2%。其中185例(35%)随访5年或更长时间,治愈率为96%。改良技术消除了氯化锌固定糊剂带来的疼痛,缩短了手术所需时间,减少了未受累正常组织的切除量,最终的缺损是一个新鲜的手术伤口,可以立即修复。由于能获得较高的5年治愈率,这些优势变得极为显著。建议将该技术用于经切除、放射治疗、刮除术和干燥术或冷冻手术等常规治疗后复发的所有肿瘤,用于临床边界不清的肿瘤,用于硬化性基底细胞上皮瘤,以及用于易复发部位的原发性皮肤癌。