Hofman P, Mainguené C, Michiels J F, Pages A, Thyss A
Department of Pathology, University of Nice, France.
Eur Arch Otorhinolaryngol. 1995;252(5):316-20. doi: 10.1007/BF00185397.
An intrathyroid primary epithelial spindle-cell tumor with mucous cysts is described in a 9-year-old child. Histologically, this well-circumscribed tumor exhibited a nodular pattern, a prominent spindle cell component with minimal pleomorphism, and well-differentiated mucinous glands within fibrous bands. The spindle cells demonstrated diffuse immunopositivity for cytokeratin and vimentin. Electron microscopy of tissue sections demonstrated that cells contained bundles of cytoplasmic tonofilaments and numerous desmosomes. The light and electron microscopic features and immunohistochemical profile of this tumor were similar to those of recently described thyroid tumors that have been called "SETTLE" tumors (i.e., spindle epithelial tumor with thymus-like differentiation). These uncommon tumors can be considered intrathyroid thymoblastomas and must be regarded as potentially malignant lesions.
本文描述了一名9岁儿童的甲状腺内原发性上皮性梭形细胞瘤伴黏液囊肿。组织学上，这个边界清楚的肿瘤呈结节状，有一个显著的梭形细胞成分，异型性极小，且在纤维束内有分化良好的黏液性腺。梭形细胞对细胞角蛋白和波形蛋白呈弥漫性免疫阳性。组织切片的电子显微镜检查显示细胞含有成束的细胞质张力丝和大量桥粒。该肿瘤的光镜和电镜特征以及免疫组化谱与最近描述的被称为“SETTLE”肿瘤（即具有胸腺样分化的梭形上皮肿瘤）相似。这些不常见的肿瘤可被视为甲状腺内胸腺瘤，必须被视为潜在的恶性病变。
