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伴有黏液囊肿的甲状腺梭形细胞瘤。是甲状腺内胸腺瘤吗?

Thyroid spindle-cell tumor with mucous cysts. An intrathyroid thymoma?

作者信息

Harach H R, Saravia Day E, Franssila K O

出版信息

Am J Surg Pathol. 1985 Jul;9(7):525-30. doi: 10.1097/00000478-198507000-00007.

DOI:10.1097/00000478-198507000-00007
PMID:4091184
Abstract

An apparently new tumor entity of the thyroid is reported. The tumor was histologically characterized by good demarcation, lobular pattern, keratin-positive spindle cells, glandular elements, stromal hyalinization, and calcifications. These findings are suggestive of a tumor related to spindle-cell thymoma and apparently closely related to the recently described entity, ectopic hamartomatous thymoma. The patient, a 23-year-old man is alive and well 10 years after diagnosis. Two histologically similar cases have earlier been reported in the English literature under the heading "malignant teratoma."

摘要

据报道,甲状腺出现了一种明显的新肿瘤实体。该肿瘤在组织学上的特征为边界清晰、小叶状结构、角蛋白阳性的梭形细胞、腺性成分、间质透明变性及钙化。这些发现提示该肿瘤与梭形细胞胸腺瘤有关,且显然与最近描述的异位错构瘤实体密切相关。该患者为一名23岁男性,诊断后10年仍健在且情况良好。在英文文献中,曾有两篇组织学相似的病例以“恶性畸胎瘤”为题早期报道过。

相似文献

1
Thyroid spindle-cell tumor with mucous cysts. An intrathyroid thymoma?伴有黏液囊肿的甲状腺梭形细胞瘤。是甲状腺内胸腺瘤吗?
Am J Surg Pathol. 1985 Jul;9(7):525-30. doi: 10.1097/00000478-198507000-00007.
2
Spindle epithelial tumor with thymus-like differentiation: a case report with cytologic, histologic, immunohistologic, and ultrastructural findings.伴有胸腺样分化的梭形上皮肿瘤:一例具有细胞学、组织学、免疫组织学及超微结构表现的病例报告
Mod Pathol. 1997 May;10(5):510-4.
3
Thyroid spindle epithelial tumor with thymus-like differentiation (the "SETTLE" tumor). An immunohistochemical and electron microscopic study.伴有胸腺样分化的甲状腺梭形上皮肿瘤(“SETTLE”肿瘤)。一项免疫组织化学和电子显微镜研究。
Eur Arch Otorhinolaryngol. 1995;252(5):316-20. doi: 10.1007/BF00185397.
4
Ectopic primary intrathyroidal thymoma: a clinicopathological and immunohistochemical analysis of 3 cases.异位原发性甲状腺内胸腺瘤:3例临床病理及免疫组化分析
Hum Pathol. 2016 Mar;49:71-6. doi: 10.1016/j.humpath.2015.10.011. Epub 2015 Nov 4.
5
[Epithelial tumors with thymus differentiation of the thyroid gland and the neck].[甲状腺及颈部具有胸腺分化的上皮性肿瘤]
Arch Anat Cytol Pathol. 1998;46(1-2):141-4.
6
[Ectopic hamartomatous thymoma: a case report and review of the literature].[异位错构瘤性胸腺瘤:一例报告及文献复习]
Ann Pathol. 2004 Apr;24(2):176-8. doi: 10.1016/s0242-6498(04)93942-9.
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Spindle epithelial tumor with thymus-like differentiation (SETTLE) of the thyroid with prominent mitotic activity and focal necrosis.
Am J Surg Pathol. 1999 Jun;23(6):712-6. doi: 10.1097/00000478-199906000-00011.
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Spindle epithelial tumor with thymuslike differentiation in a 2-year-old boy: a case report.一名2岁男孩的具有胸腺样分化的梭形上皮肿瘤:病例报告
Anal Quant Cytol Histol. 2010 Feb;32(1):53-7.
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Primary thyroid thymoma: a distinct clinicopathologic entity.原发性甲状腺胸腺瘤:一种独特的临床病理实体。
Hum Pathol. 1988 Dec;19(12):1463-7. doi: 10.1016/s0046-8177(88)80242-9.
10
Ectopic Hamartomatous Thymoma-New Insights Into a Challenging Entity: A Clinicopathologic and Immunohistochemical Study of 9 Cases.异位错构瘤性胸腺瘤——对一个具有挑战性实体的新认识:9例临床病理及免疫组化研究
Am J Surg Pathol. 2016 Nov;40(11):1571-1576. doi: 10.1097/PAS.0000000000000699.

引用本文的文献

1
Ectopic thymic tissue in the thyroid gland.甲状腺内的异位胸腺组织。
Endocr Pathol. 1993 Sep;4(3):162-164. doi: 10.1007/BF02915305.
2
Branchial and thymic remnants in the thyroid and cervical region: An explanation for unusual tumors and microscopic curiosities.甲状腺及颈部区域的鳃裂和胸腺残余:对罕见肿瘤及微观奇象的一种解释
Endocr Pathol. 1993 Sep;4(3):115-119. doi: 10.1007/BF02915299.
3
Spindle Epithelial Tumor of Thymus-like Differentiation (SETTLE) in a 3-year-old African girl.一名3岁非洲女孩患的具有胸腺样分化的梭形上皮肿瘤(SETTLE)
Clin Case Rep. 2019 Apr 25;7(6):1119-1122. doi: 10.1002/ccr3.2163. eCollection 2019 Jun.
4
Spindle epithelial tumor with thymus-like differentiation of the thyroid in a 70-year-old man.一名70岁男性甲状腺的伴胸腺样分化的梭形上皮肿瘤。
Ann Surg Treat Res. 2018 Jun;94(6):337-341. doi: 10.4174/astr.2018.94.6.337. Epub 2018 May 29.
5
Spindle epithelial tumor with thymus-like differentiation (SETTLE): clinical-pathological features, differential pathological diagnosis and therapy.伴胸腺样分化的梭形上皮肿瘤(SETTLE):临床病理特征、鉴别病理诊断及治疗
Endocrine. 2016 Mar;51(3):402-12. doi: 10.1007/s12020-015-0716-5. Epub 2015 Aug 20.
6
CASTLE tumour of the neck: a rare location of a malignant tumour of the thymus.颈部胸腺瘤:胸腺恶性肿瘤的罕见部位。
BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.06.2009.1937. Epub 2009 Dec 14.
7
Cervical thymuses exist, but no cervical thymomas develop in thoracic thymoma-prone BUF rats.颈部胸腺存在,但在胸腺瘤易感 BUF 大鼠中,没有颈部胸腺瘤发生。
Int J Exp Pathol. 2011 Apr;92(2):117-20. doi: 10.1111/j.1365-2613.2010.00755.x. Epub 2011 Feb 12.
8
Spindle epithelial tumor with thymus-like differentiation (SETTLE) of the thyroid with neck lymph node metastasis: a case report.甲状腺伴有颈部淋巴结转移的梭形上皮肿瘤伴胸腺样分化(SETTLE):一例报告
Endocr Pathol. 2005 Summer;16(2):139-43. doi: 10.1385/ep:16:2:139.
9
Childhood thyroid cancer in England and Wales.英格兰和威尔士的儿童甲状腺癌
Br J Cancer. 1995 Sep;72(3):777-83. doi: 10.1038/bjc.1995.410.
10
Thyroid spindle epithelial tumor with thymus-like differentiation (the "SETTLE" tumor). An immunohistochemical and electron microscopic study.伴有胸腺样分化的甲状腺梭形上皮肿瘤(“SETTLE”肿瘤)。一项免疫组织化学和电子显微镜研究。
Eur Arch Otorhinolaryngol. 1995;252(5):316-20. doi: 10.1007/BF00185397.