Dua K, Abbas S K, Care A D
University of Wales, Aberystwyth, Institute of Biological Sciences, UK.
Exp Physiol. 1995 Jul;80(4):589-95. doi: 10.1113/expphysiol.1995.sp003869.
Parathyroid hormone-related protein (PTHrP(1-34)) was infused into five sheep, each fitted with a large rumen cannula. After infusion, significant increases were observed in the total and ionized calcium concentrations in plasma but not in saliva. In contrast, significant decreases in the plasma concentrations of phosphate and potassium and corresponding increases in their salivary concentrations and clearance rates were observed. The salivary concentration of endogenous PTH1P(1-34) was significantly greater than that in plasma sampled simultaneously, but during the infusion of PTHrP(1-34) both plasma and salivary concentrations of PTHrP(1-34) increased.
将甲状旁腺激素相关蛋白（PTHrP(1 - 34)）注入五只装有大瘤胃瘘管的绵羊体内。注入后，观察到血浆中总钙和离子钙浓度显著升高，但唾液中未出现这种情况。相反，观察到血浆中磷酸盐和钾的浓度显著降低，同时其唾液浓度和清除率相应增加。内源性PTH1P(1 - 34)的唾液浓度显著高于同时采集的血浆浓度，但在注入PTHrP(1 - 34)期间，血浆和唾液中PTHrP(1 - 34)的浓度均升高。
