Fürst C J, Lundell M, Holm L E, Silfverswärd C
Department of General Oncology, Karolinska Hospital, Stockholm, Sweden.
J Natl Cancer Inst. 1988 Nov 2;80(17):1387-92. doi: 10.1093/jnci/80.17.1387.
The cancer incidence was studied in 18,030 patients (33% males, 67% females) with skin hemangioma who were admitted to Radiumhemmet, Karolinska Hospital, Stockholm, Sweden, 1920-1959. Radium-226 sources were used in 12,821 patients, x-ray therapy was used in 2,515 patients, and no radiotherapy was given to 2,694 patients. Cancer incidence in the cohort was searched by record linkage with the Swedish Cancer Register for the period 1958-1982. The median age was 6 months for the treated patients and 8 months for the patients not receiving radiotherapy. In the group treated with radium-226 or orthovoltage x rays (greater than or equal to 100-kV peak), 224 cancers were observed [relative risk (RR) = 1.18; 95% confidence interval (CI) = 1.03-1.35]. In patients given contact x rays, 10 cancers were observed (RR = 0.71; 95% CI = 0.34-1.30). In patients not treated with ionizing radiation, 34 cancers were observed (RR = 0.93; 95% CI = 0.64-1.29). In patients treated with radium-226 or orthovoltage x rays, an RR of 1.65 was observed for breast cancer (95% CI = 1.26-2.13) and an RR of 2.73 was found for soft tissue tumors (95% CI = 1.18-5.38). Patients with brain tumors, thyroid cancers, and bone tumors had received radiotherapy close to the tumor site more often than expected. For patients with breast cancer, no such difference was found. For cancers of the breast and thyroid, the RR was higher in patients given more than one treatment.
对1920年至1959年期间入住瑞典斯德哥尔摩卡罗林斯卡医院镭疗科的18030例皮肤血管瘤患者（33%为男性，67%为女性）的癌症发病率进行了研究。12821例患者使用了镭 - 226源，2515例患者接受了X线治疗，2694例患者未接受放射治疗。通过与瑞典癌症登记处进行记录链接，查询了该队列在1958年至1982年期间的癌症发病率。接受治疗的患者中位年龄为6个月，未接受放射治疗的患者中位年龄为8个月。在接受镭 - 226或高电压X线（峰值电压大于或等于100 kV）治疗的组中，观察到224例癌症[相对风险（RR）= 1.18；95%置信区间（CI）= 1.03 - 1.35]。接受接触性X线治疗的患者中，观察到10例癌症（RR = 0.71；95% CI = 0.34 - 1.30）。未接受电离辐射治疗的患者中，观察到34例癌症（RR = 0.93；95% CI = 0.64 - 1.29）。在接受镭 - 226或高电压X线治疗的患者中，乳腺癌的RR为1.65（95% CI = 1.26 - 2.13），软组织肿瘤的RR为2.73（95% CI = 1.18 - 5.38）。脑肿瘤、甲状腺癌和骨肿瘤患者接受肿瘤部位附近放射治疗的频率高于预期。对于乳腺癌患者，未发现此类差异。对于乳腺癌和甲状腺癌，接受多次治疗的患者RR更高。
