Zaccaro L, Falcone M L, Silva S, Bigalli L, Cecchettini A, Giorgi F, Malvaldi G, Bendinelli M
Centro Retrovirus, Università di Pisa, Italy.
AIDS Res Hum Retroviruses. 1995 Jun;11(6):747-52. doi: 10.1089/aid.1995.11.747.
Flow cytometry has been employed to study NK cell cytotoxic activity in cats infected with feline immunodeficiency virus. The results show that animals infected for 12 months or more have decreased levels of NK cell cytotoxic activity in their blood. The impairment could not be overcome by in vitro treatment of effector cells with interleukin 2. Additional results suggest that the NK cells of infected cats are defective, in that they are still able to bind to target cells but have a reduced ability to kill them.
流式细胞术已被用于研究感染猫免疫缺陷病毒的猫的自然杀伤（NK）细胞的细胞毒性活性。结果表明，感染12个月或更长时间的动物血液中NK细胞的细胞毒性活性水平降低。用白细胞介素2对效应细胞进行体外处理无法克服这种损伤。其他结果表明，受感染猫的NK细胞存在缺陷，因为它们仍然能够与靶细胞结合，但杀伤靶细胞的能力降低。
