Hanlon M A, Marr J M, Hayes K A, Mathes L E, Stromberg P C, Ringler S, Krakowka S, Lafrado L J
Ohio State University College of Dentistry, Columbus.
Viral Immunol. 1993 Summer;6(2):119-24. doi: 10.1089/vim.1993.6.119.
Experimental infection with the Mt. Airy isolate of feline immunodeficiency virus (FIVMA), a lentivirus isolated from a domestic cat exhibiting signs of an immunodeficiency-like syndrome, results in transient lymphadenopathy, fever, stomatitis, enteritis, neurologic abnormalities, and immunosuppression. The effects of FIVMA infection on neutrophil and natural killer cell (NK) function were examined in vitro. Suppression of neutrophil chemiluminescence (CL) responses, as well as reduction in NK-mediated cytotoxicity were demonstrated. Neutrophil CL was decreased by 50% in infected cats when compared to control values. This loss of CL was present through 6 months after infection. In addition, NK-mediated cytotoxicity was approximately 50% less in FIVMA infected cats than in controls. Loss of innate immunity was paralleled with inversion in feline CD4/CD8 lymphocyte ratios and decreases in lymphocyte mitogenesis seen as early as 5 weeks after infection. These results suggest that FIVMA infection induces an immunodeficiency disorder in infected cats similar to that seen in human immunodeficiency virus infections.
用猫免疫缺陷病毒（FIVMA）的艾里山分离株进行实验性感染，该慢病毒从一只表现出免疫缺陷样综合征症状的家猫中分离得到，会导致短暂的淋巴结病、发热、口腔炎、肠炎、神经异常和免疫抑制。在体外研究了FIVMA感染对中性粒细胞和自然杀伤细胞（NK）功能的影响。结果表明，中性粒细胞化学发光（CL）反应受到抑制，NK介导的细胞毒性也降低。与对照值相比，感染猫的中性粒细胞CL降低了50%。这种CL的丧失在感染后6个月内一直存在。此外，FIVMA感染猫的NK介导的细胞毒性比对照组大约低50%。先天性免疫的丧失与猫CD4/CD8淋巴细胞比率的倒置以及早在感染后5周就出现的淋巴细胞有丝分裂减少同时出现。这些结果表明，FIVMA感染在感染猫中诱发了一种免疫缺陷疾病，类似于人类免疫缺陷病毒感染中所见的疾病。
