Kamibayashi L, Wyss U P, Cooke T D, Zee B
Department of Anatomy and Cell Biology, Queen's University, Kingston, Canada.
Bone. 1995 Jul;17(1):27-35. doi: 10.1016/8756-3282(95)00137-3.
The microstructural characteristics of osteoarthritic subchondral bone in the medial tibial condyle are clearly different from normal age-matched bone. Subchondral sclerosis in osteoarthritis indicates not only an increase in bone volume fraction but also alteration in other microstructural characteristics. Eleven medial tibial condyles were collected from ten subjects during arthroplastic surgery for knee oseoarthritis. They were compared to four medial tibial condyles from four age-matched controls with no history of any bone or joint disorder. Six sections from anterior to posterior and three levels from proximal to distal were evaluated in each medial condyle. Five histomorphometric parameters were measured: bone volume fraction (BVf), trabecular thickness (Tb.Th), trabecular number (Tb.N), trabecular separation (Tb.S), and trabecular connectivity (Tb.C). In general, the osteoarthritic subchondral bone had a higher bone volume fraction than control bone but the microstructure was characterized by fewer, widely spaced, thicker than normal trabeculae. There were also highly localized regional differences by depth from the articular surface and from anterior to posterior across the medial condyle. These variations in OA subchondral bone microstructure may significantly affect biomechanical competence of bone in a way not predictable by bone volume fraction measurements alone.
胫骨内侧髁骨关节炎软骨下骨的微观结构特征与年龄匹配的正常骨明显不同。骨关节炎中的软骨下硬化不仅表明骨体积分数增加，还表明其他微观结构特征发生改变。在膝关节骨关节炎关节成形手术期间，从10名受试者身上收集了11个胫骨内侧髁。将它们与4名年龄匹配、无任何骨骼或关节疾病史的对照者的4个胫骨内侧髁进行比较。对每个内侧髁从前到后取6个切片，从近端到远端取3个层面进行评估。测量了5个组织形态计量学参数：骨体积分数（BVf）、小梁厚度（Tb.Th）、小梁数量（Tb.N）、小梁间距（Tb.S）和小梁连接性（Tb.C）。一般来说，骨关节炎软骨下骨的骨体积分数高于对照骨，但其微观结构的特征是小梁数量减少、间距变宽且比正常小梁更厚。在内侧髁，从关节表面到深部以及从前到后还存在高度局部化的区域差异。骨关节炎软骨下骨微观结构的这些变化可能会以一种仅通过骨体积分数测量无法预测的方式显著影响骨骼的生物力学性能。
