Shimizu M, Tsuji H, Matsui H, Katoh Y, Sano A
Department of Orthopaedic Surgery, Toyama Medical and Pharmaceutical University, Japan.
Clin Orthop Relat Res. 1993 Aug(293):229-39.
Tibial condyles in 11 patients with knee joint osteoarthrosis were analyzed by subchondral bone morphometry using 11 static parameters. The results were evaluated by comparison with the grade of joint cartilage degeneration in relation to the external, intermediate, and internal areas of the tibial condyle. The bone morphometric data also were analyzed according to the depth of layers, from the surface to the depth of 2000 microns of the bone. A parallel relationship between the bone volume/bone formation activity and the Mankin grade of cartilage degeneration was noted in both medial and lateral condyles. Bone resorption activity in the medial condyle was found only in the external and intermediate areas; it was extremely low in the lateral condyle. Throughout the observation areas, the values of bone volume in relation to depth were highest in the superficial layer with a gradual decrease as the depth increased. The bone formation activity was highest in the superficial layer in the lateral condyle, whereas in the medial condyle, it was highest in the layer between 1000 and 1500 microns in depth. The bone resorption activity showed no variations according to the depth. The progression of joint cartilage degeneration was associated with remodeling of the underlying subchondral bone.
使用11个静态参数，通过软骨下骨形态测量法对11例膝关节骨关节炎患者的胫骨髁进行分析。通过与胫骨髁外部、中间和内部区域的关节软骨退变程度进行比较来评估结果。骨形态测量数据也根据从骨表面到2000微米深度的层次进行分析。在内侧和外侧髁中均发现骨体积/骨形成活性与软骨退变的曼金分级之间存在平行关系。内侧髁的骨吸收活性仅在外部和中间区域发现；外侧髁的骨吸收活性极低。在整个观察区域，与深度相关的骨体积值在表层最高，随着深度增加逐渐降低。外侧髁的骨形成活性在表层最高，而在内侧髁，骨形成活性在深度1000至1500微米的层中最高。骨吸收活性未随深度变化。关节软骨退变的进展与下方软骨下骨的重塑有关。
