Mejía L A, Arroyave G
Am J Clin Nutr. 1982 Jul;36(1):87-93. doi: 10.1093/ajcn/36.1.87.
The effect of improvement in vitamin A nutriture on biochemical indicators of iron nutrition during national vitamin A fortification of sugar was investigated longitudinally. Four "paired-comparison-subgroups" of preschoolers were studied before fortification (survey I) and, respectively, at 6 months (survey I versus II), at 1 yr (survey I versus III), at 1 1/2 yr (survey I versus IV), and at 2 yr (survey I versus V) after fortification began. Comparing I versus II gave a positive correlation (p less than 0.001) between changes in serum retinol or retinol-binding protein and changes in iron, total iron binding capacity, and percentage transferrin saturation. In contrast, changes in serum ferritin correlated negatively (p less than 0.05). Comparing V with I, retinol, retinol-binding protein, iron, and percentage transferritin saturation increased, but ferritin also increased (p less than 0.05). Consequently, the distribution of serum iron and ferritin values of the children improved (p less than 0.05). Because dietary iron did not change through the study period, the results suggest that vitamin A fortification had a favorable effect on iron metabolism and nutritional status.
在全国范围内对食糖进行维生素A强化期间，纵向研究了维生素A营养状况改善对铁营养生化指标的影响。在强化前（调查I）以及强化开始后6个月（调查I与II对比）、1年（调查I与III对比）、1.5年（调查I与IV对比）和2年（调查I与V对比），分别对四组学龄前儿童进行了“配对比较亚组”研究。比较I与II时，血清视黄醇或视黄醇结合蛋白的变化与铁、总铁结合力和转铁蛋白饱和度百分比的变化呈正相关（p<0.001）。相比之下，血清铁蛋白的变化呈负相关（p<0.05）。比较V与I时，视黄醇、视黄醇结合蛋白、铁和转铁蛋白饱和度百分比增加，但铁蛋白也增加（p<0.05）。因此，儿童血清铁和铁蛋白值的分布得到改善（p<0.05）。由于在研究期间膳食铁没有变化，结果表明维生素A强化对铁代谢和营养状况有有利影响。
