Teranishi Y, Mizutani H, Murata M, Shimizu M, Matsushima K
Department of Dermatology, Mie University, Faculty of Medicine, Japan.
J Dermatol Sci. 1995 Jul;10(1):8-15. doi: 10.1016/0923-1811(95)00384-5.
To evaluate the contribution of peripheral blood monocytes (PBMC) to epidermotropic inflammatory reactions in psoriasis, using an enzyme-linked immunosorbent assay we measured spontaneous interleukin-8 (IL-8) production in PBMC obtained from patients with psoriasis. IL-8 production in the psoriatic PBMC was significantly higher than that in normal control PBMC. Plasma IL-8 levels in psoriatic patients were also moderately increased compared to normal control levels. IL-8 production in PBMC was closely related to the clinical severity of psoriasis and to the response to treatment, including systemic methotrexate (MTX) treatment and tonsillectomy. IL-8 production in PBMC was also positively related to the production of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in these cells. We speculate that the chemotactic cytokine IL-8 contributes to the development of psoriatic skin lesions, and mediates inflammatory reactions from the inflammatory focus to the psoriatic lesions.
为评估外周血单核细胞（PBMC）在银屑病向表皮趋化性炎症反应中的作用，我们采用酶联免疫吸附测定法，检测了银屑病患者外周血单核细胞中白细胞介素-8（IL-8）的自发产生情况。银屑病患者外周血单核细胞中IL-8的产生显著高于正常对照外周血单核细胞。与正常对照水平相比，银屑病患者血浆IL-8水平也有适度升高。外周血单核细胞中IL-8的产生与银屑病的临床严重程度以及对治疗的反应密切相关，这些治疗包括全身甲氨蝶呤（MTX）治疗和扁桃体切除术。外周血单核细胞中IL-8的产生也与这些细胞中白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）的产生呈正相关。我们推测，趋化细胞因子IL-8有助于银屑病皮肤病变的发展，并介导从炎症灶到银屑病病变的炎症反应。
