Skinner R
Sir James Spence Institute of Child Health, University of Newcastle upon Tyne, Royal Victoria Infirmary, UK.
Curr Opin Oncol. 1995 Jul;7(4):310-5. doi: 10.1097/00001622-199507000-00003.
Nephrotoxicity is a relatively common and potentially serious adverse effect of treatment with certain cytotoxic drugs (especially ifosfamide). The patient may develop severe chronic proximal tubular toxicity. It is therefore very important to attempt to reduce the frequency and severity of acute and chronic nephrotoxicity resulting from chemotherapy. A logical approach is described, with particular reference to ifosfamide and cisplatin, involving improved evaluation of the important clinical features of nephrotoxicity and a greater understanding of its pathogenesis. This approach will facilitate the development of logical preventive strategies, or less toxic analogues, or both. The methods used may also enable prediction of the potential nephrotoxicity of newly developed cytotoxic agents.
肾毒性是某些细胞毒性药物（尤其是异环磷酰胺）治疗相对常见且可能严重的不良反应。患者可能会出现严重的慢性近端肾小管毒性。因此，试图降低化疗引起的急性和慢性肾毒性的频率和严重程度非常重要。本文描述了一种合理的方法，特别提及异环磷酰胺和顺铂，包括改进对肾毒性重要临床特征的评估以及对其发病机制的更深入理解。这种方法将有助于制定合理的预防策略，或研发毒性较小的类似物，或两者兼而有之。所采用的方法还可能有助于预测新研发的细胞毒性药物的潜在肾毒性。
