Zuijderhoudt F M, Dorresteijn-de Bok J, te Velde K
Department of Clinical Chemistry, Deventer Ziekenhuis, The Netherlands.
Eur J Clin Chem Clin Biochem. 1995 May;33(5):285-8. doi: 10.1515/cclm.1995.33.5.285.
We compared a spectrophotometric screening test measuring faecal porphyrin concentration with an HPLC method. There was a good overall correlation between both methods although some scatter was observed. ROC plot analysis of the screening test leads to a cut-off value of 35 nmol porphyrin per g faeces, wet weight with a sensitivity of 97% and a specificity of 96%. These results indicate that the screening test is quite useful for detection of increased total faecal porphyrin concentration, but less useful in accurate measurement of increased total faecal porphyrin concentration.
我们将一种测量粪便卟啉浓度的分光光度筛选试验与高效液相色谱法进行了比较。尽管观察到一些离散情况，但两种方法总体相关性良好。筛选试验的ROC曲线分析得出每克粪便（湿重）中卟啉的临界值为35 nmol，灵敏度为97%，特异性为96%。这些结果表明，该筛选试验对于检测粪便总卟啉浓度升高相当有用，但在准确测量粪便总卟啉浓度升高方面用处较小。
